Universität zu Köln

Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stavrinou, Pantelis ORCID: 0000-0001-8653-1395, Lipke, Katharina, Bauer, Elena K., Ceccon, Garry, Werner, Jan-Michael, Neumaier, Bernd, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim J., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2019). FET PET reveals considerable spatial differences in tumour burden compared to conventional MRI in newly diagnosed glioblastoma. Eur. J. Nucl. Med. Mol. Imaging, 46 (3). S. 591 - 603. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

PurposeAreas of contrast enhancement (CE) on MRI are usually the target for resection or radiotherapy target volume definition in glioblastomas. However, the solid tumour mass may extend beyond areas of CE. Amino acid PET can detect parts of the tumour that show no CE. We systematically investigated tumour volumes delineated by amino acid PET and MRI in patients with newly diagnosed, untreated glioblastoma.MethodsPreoperatively, 50 patients with neuropathologically confirmed glioblastoma underwent O-(2-[F-18]-fluoroethyl)-l-tyrosine (FET) PET, and fluid-attenuated inversion recovery (FLAIR) and contrast-enhanced MRI. Areas of CE were manually segmented. FET PET tumour volumes were segmented using a tumour-to-brain ratio of 1.6. The percentage overlap volumes, and Dice and Jaccard spatial similarity coefficients (DSC, JSC) were calculated. FLAIR images were evaluated visually.ResultsIn 43 patients (86%), the FET tumour volume was significantly larger than the CE volume (21.514.3mL vs. 9.4 +/- 11.3mL; P<0.001). Forty patients (80%) showed both increased uptake of FET and CE. In these 40 patients, the spatial similarity between FET uptake and CE was low (mean DSC 0.39 +/- 0.21, mean JSC 0.26 +/- 0.16). Ten patients (20%) showed no CE, and one of these patients showed no FET uptake. In five patients (10%), increased FET uptake was present outside areas of FLAIR hyperintensity.ConclusionOur results show that the metabolically active tumour volume delineated by FET PET is significantly larger than tumour volume delineated by CE. Furthermore, the results strongly suggest that the information derived from both imaging modalities should be integrated into the management of patients with newly diagnosed glioblastoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED orcid.org/0000-0001-8653-1395 UNSPECIFIED Lipke, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Elena K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jan-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156136
DOI:	10.1007/s00259-018-4188-8
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	46
Number:	3
Page Range:	S. 591 - 603
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; HIGH-GRADE GLIOMAS; TARGET DELINEATION; MALIGNANT GLIOMA; CONTRAST ENHANCEMENT; EUROPEAN ASSOCIATION; COMPUTED-TOMOGRAPHY; F-18-FET PET; RESECTION; EXTENT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15613