Universität zu Köln

Heeger, Christian-Hendrik, Bellmann, Barbara, Fink, Thomas, Bohnen, Jan-Eric, Wissner, Erik, Wohlmuth, Peter, Rottner, Laura, Sohns, Christian, Tilz, Roland Richard, Mathew, Shibu, Reissmann, Bruno, Lemes, Christine, Maurer, Tilman, Lueker, Jakob, Sultan, Arian, Plenge, Tobias, Goldmann, Britta, Ouyang, Feifan, Kuck, Karl-Heinz, Metzner, Ilka, Metzner, Andreas, Steven, Daniel and Rillig, Andreas (2019). Efficacy and safety of cryoballoon ablation in the elderly: A multicenter study. Int. J. Cardiol., 278. S. 108 - 114. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Background: The prevalence of atrial fibrillation (AF) increases with age. Second-generation cryoballoon (CB2)based PVI has demonstrated encouraging clinical results in the treatment of paroxysmal (PAF) and persistent atrial fibrillation (PersAF). The objective of this study was to assess data on safety, efficacy and long-term clinical success of CB2-based pulmonary vein isolation (PVI) in patients =75 years of age. Methods: CB2-based PVI was performed in 104 patients =75 years of age (elderly group) and symptomatic AF (PersAF: n =44, 42.3%) in three highly experienced German EP centers. The data was compared to propensity score matched patients with age b75 years (n =104, control group; PersAF: n =45, 43.3%, p=0.956). Results: Themedian age of the elderly groupwas 77.5 [75, 80] yearswhile itwas 63 [52, 70] years of control group patients (p=0.0001). The median procedure time was 92.5 [75, 120] minutes (elderly group) and 100 [75, 120] (control group), p =0.124. Major complications were registered in 7/ 104 (6.7%) elderly patients and 7/ 104 (6.7%) control group patients (p =0.999). Clinical success in terms of freedom from AF recurrence after oneyear follow-up was 80% (95% CI: 72-88) and 82% (95% CI: 75-90) and after three-year follow-up 59% (95% CI: 47-74) and 49% (95% CI: 37 64) for the elderly group and the control group, respectively (p=0.7). Conclusions: CB2-based PVI in patients =75 years of age appears safe, is associated with low procedure times and shows promising clinical success rates equal to patients of the younger population. (c) 2018 Elsevier B. V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heeger, Christian-Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Bellmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bohnen, Jan-Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Wissner, Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlmuth, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottner, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Sohns, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tilz, Roland Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathew, Shibu UNSPECIFIED UNSPECIFIED UNSPECIFIED Reissmann, Bruno UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemes, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueker, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Sultan, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Plenge, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldmann, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Ouyang, Feifan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuck, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzner, Ilka UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzner, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rillig, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156161
DOI:	10.1016/j.ijcard.2018.09.090
Journal or Publication Title:	Int. J. Cardiol.
Volume:	278
Page Range:	S. 108 - 114
Date:	2019
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULMONARY VEIN ISOLATION; PAROXYSMAL ATRIAL-FIBRILLATION; PHRENIC-NERVE PALSY; 2016 ESC GUIDELINES; CATHETER ABLATION; RADIOFREQUENCY ABLATION; PROCEDURAL EFFICACY; 2ND-GENERATION; MANAGEMENT; COLLABORATION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15616