Universität zu Köln

von Twickel, Arndt, Kowatschew, Daniel, Saltuerk, Mehmet, Schauer, Maria, Robertson, Brita, Korsching, Sigrun ORCID: 0000-0002-5450-172X, Walkowiak, Wolfgang, Grillner, Sten and Perez-Fernandez, Juan ORCID: 0000-0001-7109-951X (2019). Individual Dopaminergic Neurons of Lamprey SNc/VTA Project to Both the Striatum and Optic Tectum but Restrict Co-release of Glutamate to Striatum Only. Curr. Biol., 29 (4). S. 677 - 692. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

Dopaminergic neurons in the substantia nigra (SNc) innervate both striatum and the superior colliculus in mammals, as well as its homolog the optic tectum in lampreys, belonging to the oldest group of living verte-brates [1-3]. In the lamprey, we have previously shown that the same neuron sends axonal branches to both striatum and the optic tectum [3]. Here, we show that most neurons in the lamprey SNc and ventral tegmental area (VTA) (also referred to as the nucleus of the posterior tuberculum) express not only tyrosine hydroxylase (TH), in lamprey a marker of dopaminergic neurons [4], but also the vesicular glutamate transporter (vGluT), suggesting that glutamate is a co-transmitter. Remarkably, the axonal branches that project to striatum elicit both dopaminergic and glutamatergic synaptic effects on striatal neurons, whereas the axonal projections to the optic tectum only evoke dopaminergic effects. Thus, axonal branches from the same neuron can use two transmitters in one branch and only one in the other. Previous studies suggest that, along an individual dopaminergic axon, there can be microdomains of either TH or vGluT [5-8]. In addition, the present results demonstrate that entire axonal branches to one target structure can differ from that of branches to another target, both originating from the same dopamine neuron. This implies that a given dopamine neuron can exert different effects on two different target structures. The combined release of dopamine and glutamate may be appropriate in striatum, whereas the effects exerted on the tectal motor center may be better served with a selective dopaminergic modulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Twickel, Arndt UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowatschew, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Saltuerk, Mehmet UNSPECIFIED UNSPECIFIED UNSPECIFIED Schauer, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Robertson, Brita UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED Walkowiak, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Grillner, Sten UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez-Fernandez, Juan UNSPECIFIED orcid.org/0000-0001-7109-951X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156490
DOI:	10.1016/j.cub.2019.01.004
Journal or Publication Title:	Curr. Biol.
Volume:	29
Number:	4
Page Range:	S. 677 - 692
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-AMINOBUTYRIC-ACID; SEA LAMPREY; SUBSTANTIA-NIGRA; SYSTEM; COLOCALIZATION; CONNECTIVITY; EXPRESSION; VGLUT2 Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15649