Universität zu Köln

Mueck, Alfred O. and Roemer, Thomas (2019). Choice of progestogen for endometrial protection in combination with transdermal estradiol in menopausal women. Horm. Mol. Biol. Clin. Investig., 37 (2). BERLIN: WALTER DE GRUYTER GMBH. ISSN 1868-1891

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Abstract

Transdermal estradiol (TE) application (using gels, patches or a novel spray) is now a preferred route of hormone therapy (HT) in menopausal women, because various risks such as venous thromboembolism, stroke and unwanted hepatic effects can be reduced compared with oral HT. However, in the presence of an intact uterus, concurrent administration of progestogen is needed for endometrial protection. Due to the variety of progestogens available and differences in their clinical effects, the selection of the most appropriate substance and dosing for individual combination therapy can be difficult. This is especially true for TE gels and the novel spray because no fixed combination products are commercially available, meaning all progestogens must be added separately, and even for patches only two transdermal synthetic progestogens are available. The aim of this review was to summarize data on the endometrial effects of the different progestogens and to provide practical recommendations for the choice of progestogen (type and dosing), with a focus on endometrial protection when using TE, especially when using the novel estradiol (E2) spray.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueck, Alfred O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roemer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157085
DOI:	10.1515/hmbci-2018-0033
Journal or Publication Title:	Horm. Mol. Biol. Clin. Investig.
Volume:	37
Number:	2
Date:	2019
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1868-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HORMONE-REPLACEMENT THERAPY; CONTINUOUS COMBINED ESTROGEN; FACTOR-BINDING PROTEIN-1; POSTMENOPAUSAL WOMEN; BLEEDING PATTERNS; MICRONIZED PROGESTERONE; MG 17-BETA-ESTRADIOL; VAGINAL PROGESTERONE; DOUBLE-BLIND; FOLLOW-UP Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15708