Universität zu Köln

Schwartz, Frank, Tahmasian, Masoud ORCID: 0000-0002-8304-2876, Maier, Franziska, Rochhausen, Luisa, Schnorrenberg, Kim L., Samea, Fateme, Seemiller, Joseph ORCID: 0000-0001-7742-8759, Zarei, Mojtaba, Sorg, Christian, Drzezga, Alexander, Timmermann, Lars, Meyer, Thomas D., van Eimeren, Thilo and Eggers, Carsten (2019). Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson's disease. Brain Imaging Behav., 13 (1). S. 241 - 255. NEW YORK: SPRINGER. ISSN 1931-7565

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Abstract

Impulsivity and hypomania are common non-motor features in Parkinson's disease (PD). The aim of this study was to find the overlapping and distinct neural correlates of these symptoms in PD. Symptoms of impulsivity and hypomania were assessed in 24 PD patients using the Barratt Impulsiveness Scale (BIS-11) and Self-Report Manic Inventory (SRMI), respectively. In addition, fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for each individual was performed. We conducted two separate multiple regression analyses for BIS-11 and SRMI scores with FDG-PET data to identify the brain regions that are associated with both impulsivity and hypomania scores, as well as those exclusive to each symptom. Then, seed-based functional connectivity analyses on healthy subjects identified the areas connected to each of the exclusive regions and the overlapping region, used as seeds. We observed a positive association between BIS-11 and SRMI scores and neural metabolism only in the prefrontal areas. Conjunction analysis revealed an overlapping region in the middle frontal gyrus. Regions exclusive to impulsivity were found in the medial part of the right superior frontal gyrus and regions exclusive to hypomania were in the right superior frontal gyrus, right precentral gyrus and right paracentral lobule. Connectivity patterns of seeds exclusively related to impulsivity were different from those for hypomania in healthy brains. These results provide evidence of both overlapping and distinct regions linked with impulsivity and hypomania scores in PD. The exclusive regions for each characteristic are connected to specific intrinsic functional networks.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwartz, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0002-8304-2876 UNSPECIFIED Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Rochhausen, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnorrenberg, Kim L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Samea, Fateme UNSPECIFIED UNSPECIFIED UNSPECIFIED Seemiller, Joseph UNSPECIFIED orcid.org/0000-0001-7742-8759 UNSPECIFIED Zarei, Mojtaba UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Thomas D. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157284
DOI:	10.1007/s11682-017-9812-x
Journal or Publication Title:	Brain Imaging Behav.
Volume:	13
Number:	1
Page Range:	S. 241 - 255
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1931-7565
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; BORDERLINE PERSONALITY-DISORDER; DOPAMINE REPLACEMENT THERAPY; REGIONAL HOMOGENEITY; NETWORK CONNECTIVITY; PREFRONTAL CORTEX; BIPOLAR DISORDER; DECISION-MAKING; ABNORMALITIES; DYSFUNCTION Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15728