Universität zu Köln

Harmsen, Stefan ORCID: 0000-0001-5812-7299, Rogalla, Stephan, Huang, Ruimin, Spaliviero, Massimiliano, Neuschmelting, Volker, Hayakawa, Yoku ORCID: 0000-0002-3988-2499, Lee, Yoomi, Tailor, Yagnesh, Toledo-Crow, Ricardo, Kang, Jeon Woong, Samii, Jason M., Karabeber, Hazem, Davis, Ryan M., White, Julie R., van de Rijn, Matt, Gambhir, Sanjiv S., Contag, Christopher H., Wang, Timothy C. and Kircher, Moritz F. (2019). Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy. ACS Nano, 13 (2). S. 1354 - 1365. WASHINGTON: AMER CHEMICAL SOC. ISSN 1936-086X

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Abstract

Cancers of the gastrointestinal (GI) tract are among the most frequent and most lethal cancers worldwide. An important reason for this high mortality is that early disease is typically asymptomatic, and patients often present with advanced, incurable disease. Even in high-risk patients who routinely undergo endoscopic screening, lesions can be missed due to their small size or subtle appearance. Thus, current imaging approaches lack the sensitivity and specificity to accurately detect incipient GI tract cancers. Here we report our finding that a single dose of a high-sensitivity surface-enhanced resonance Raman scattering nanoparticle (SERRS-NP) enables reliable detection of precancerous GI lesions in animal models that closely mimic disease development in humans. Some of these animal models have not been used previously to evaluate imaging probes for early cancer detection. The studies were performed using a commercial Raman imaging system, a newly developed mouse Raman endoscope, and finally a clinically applicable Raman endoscope for larger animal studies. We show that this SERRS-NP-based approach enables robust detection of small, premalignant lesions in animal models that faithfully recapitulate human esophageal, gastric, and colorectal tumorigenesis. This method holds promise for much earlier detection of GI cancers than currently possible and could lead therefore to marked reduction of morbidity and mortality of these tumor types.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Harmsen, Stefan UNSPECIFIED orcid.org/0000-0001-5812-7299 UNSPECIFIED Rogalla, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Ruimin UNSPECIFIED UNSPECIFIED UNSPECIFIED Spaliviero, Massimiliano UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuschmelting, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayakawa, Yoku UNSPECIFIED orcid.org/0000-0002-3988-2499 UNSPECIFIED Lee, Yoomi UNSPECIFIED UNSPECIFIED UNSPECIFIED Tailor, Yagnesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Toledo-Crow, Ricardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kang, Jeon Woong UNSPECIFIED UNSPECIFIED UNSPECIFIED Samii, Jason M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karabeber, Hazem UNSPECIFIED UNSPECIFIED UNSPECIFIED Davis, Ryan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED White, Julie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED van de Rijn, Matt UNSPECIFIED UNSPECIFIED UNSPECIFIED Gambhir, Sanjiv S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Contag, Christopher H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Timothy C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, Moritz F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157334
DOI:	10.1021/acsnano.8b06808
Journal or Publication Title:	ACS Nano
Volume:	13
Number:	2
Page Range:	S. 1354 - 1365
Date:	2019
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1936-086X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BARRETTS-ESOPHAGUS; COLORECTAL-CANCER; INTESTINAL METAPLASIA; APC MUTATIONS; MOUSE MODEL; APC(MIN); COLONOSCOPY; RECURRENCE; RESECTION; TUMORS Multiple languages Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15733