Universität zu Köln

Stegmayr, Carina ORCID: 0000-0003-4191-8734, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Kops, Elena Rota, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Shah, Nadim J., Neumaier, Bernd and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2019). Influence of Dexamethasone on O-(2-[F-18]-Fluoroethyl)-l-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake. Mol. Imaging. Biol., 21 (1). S. 168 - 175. NEW YORK: SPRINGER. ISSN 1860-2002

Full text not available from this repository.

Abstract

PurposeO-(2-[F-18]fluoroethyl)-l-tyrosine ([F-18]FET) is an established positron emission tomography (PET) tracer for brain tumor imaging. This study explores the influence of dexamethasone therapy on [F-18]FET uptake in the normal brain and its influence on the maximum and mean tumor-to-brain ratio (TBR).Procedures[F-18]FET PET scans of 160 brain tumor patients were evaluated (80 dexamethasone treated, 80 untreated; each group with 40 men/40 women). The standardized uptake value of [F-18]FET uptake in the normal brain (SUVbrain) in the different groups was compared. Nine patients were examined repeatedly with and without dexamethasone therapy.ResultsSUV(brain) of [F-18]FET uptake was significantly higher in dexamethasone-treated patients than in untreated patients (SUVbrain 1.330.1 versus 1.06 +/- 0.16 in male and 1.45 +/- 0.25 versus 1.31 +/- 0.28 in female patients). Similar results were observed in patients with serial PET scans. Furthermore, compared to men, a significantly higher SUVbrain was found in women, both with and without dexamethasone treatment. There were no significant differences between the different groups for TBRmax and TBRmean, which could have been masked by the high standard deviation. In a patient with a stable brain metastasis investigated twice with and without dexamethasone, the TBRmax and the biological tumor volume (BTV) decreased considerably after dexamethasone due to an increased SUVbrain.ConclusionDexamethasone treatment appears to increase the [F-18]FET uptake in the normal brain. An effect on TBRmax, TBRmean, and BTV cannot be excluded which should be considered especially for treatment monitoring and the estimation of BTV using [F-18]FET PET.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stegmayr, Carina UNSPECIFIED orcid.org/0000-0003-4191-8734 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157676
DOI:	10.1007/s11307-018-1221-z
Journal or Publication Title:	Mol. Imaging. Biol.
Volume:	21
Number:	1
Page Range:	S. 168 - 175
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-2002
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language O-(2-F-18-FLUOROETHYL)-L-TYROSINE UPTAKE; BARRIER PERMEABILITY; F-18-FET PET; DIAGNOSIS; THERAPY; BALANCE; SEX Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15767