Johnen, Andreas, Buerkner, Paul-Christian, Landmeyer, Nils C., Ambrosius, Bjoern, Calabrese, Pasquale, Motte, Jeremias ORCID: 0000-0002-6624-8565, Hessler, Nicole, Antony, Gisela, Koenig, Inke R., Klotz, Luisa, Hoshi, Muna-Miriam, Aly, Lilian ORCID: 0000-0002-7051-124X, Groppa, Sergiu ORCID: 0000-0002-2551-5655, Luessi, Felix, Paul, Friedemann, Tackenberg, Bjoern, Bergh, Florian Then, Kuempfel, Tania, Tumani, Hayrettin, Stangel, Martin, Weber, Frank, Bayas, Antonios, Wildemann, Brigitte, Heesen, Christoph, Zettl, Uwe K., Zipp, Frauke, Hemmer, Bernhard, Meuth, Sven G., Gold, Ralf, Wiendl, Heinz, Salmen, Anke ORCID: 0000-0002-4751-299X, Demir, Seray, Schroeder, Christoph, Voithenleitner, Lisa A., Berthele, Achim, Haars, Sarah, Nischwitz, Sandra, Knop, Matthias J., Rothacher, Susanne, Poettgen, Jana, Warnke, Clemens, Linker, Ralf A. and Ziemann, Ulf (2019). Can we predict cognitive decline after initial diagnosis of multiple sclerosis? Results from the German National early MS cohort (KKNMS). J. Neurol., 266 (2). S. 386 - 398. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

BackgroundCognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI and progression after initial diagnosis.MethodsNeuropsychological screening data from baseline and 1-year follow-up of a prospective multicenter cohort study (NationMS) involving 1123 patients with newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical and conventional MRI markers at baseline were predictive for CI and longitudinal cognitive changes.ResultsAt baseline, 22% of patients had CI (impairment in 2 cognitive domains) with highest frequencies and severity in processing speed and executive functions. Demographics (fewer years of academic education, higher age, male sex), clinical (EDSS, depressive symptoms) but no conventional MRI characteristics were linked to baseline CI. At follow-up, only 14% of patients showed CI suggesting effects of retesting. Neither baseline characteristics nor initiation of treatment between baseline and follow-up was able to predict cognitive changes within the follow-up period of 1 year.ConclusionsIdentification of risk factors for short-term cognitive change in newly diagnosed MS or CIS is insufficient using only demographic, clinical and conventional MRI data. Change-sensitive, re-test reliable cognitive tests and more sophisticated predictors need to be employed in future clinical trials and cohort studies of early-stage MS to improve prediction.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Johnen, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerkner, Paul-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landmeyer, Nils C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ambrosius, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calabrese, PasqualeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Motte, JeremiasUNSPECIFIEDorcid.org/0000-0002-6624-8565UNSPECIFIED
Hessler, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antony, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, Inke R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klotz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoshi, Muna-MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aly, LilianUNSPECIFIEDorcid.org/0000-0002-7051-124XUNSPECIFIED
Groppa, SergiuUNSPECIFIEDorcid.org/0000-0002-2551-5655UNSPECIFIED
Luessi, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tackenberg, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergh, Florian ThenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuempfel, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tumani, HayrettinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stangel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayas, AntoniosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wildemann, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zettl, Uwe K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zipp, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meuth, Sven G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gold, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiendl, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmen, AnkeUNSPECIFIEDorcid.org/0000-0002-4751-299XUNSPECIFIED
Demir, SerayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voithenleitner, Lisa A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthele, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haars, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nischwitz, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knop, Matthias J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothacher, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poettgen, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linker, Ralf A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziemann, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-157993
DOI: 10.1007/s00415-018-9142-y
Journal or Publication Title: J. Neurol.
Volume: 266
Number: 2
Page Range: S. 386 - 398
Date: 2019
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1459
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIGIT MODALITIES TEST; IMPAIRMENT; MRI; DYSFUNCTION; CRITERIA; TESTSMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15799

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