Universität zu Köln

Hu, Xiaochen, Teunissen, Charlotte E., Spottke, Annika, Heneka, Michael T., Duezel, Emrah, Peters, Oliver, Li, Siyao, Priller, Josef ORCID: 0000-0001-7596-0979, Buerger, Katharina, Teipel, Stefan, Laske, Christoph, Verfaillie, Sander C. J., Barkhof, Frederik ORCID: 0000-0003-3543-3706, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Rami, Lorena, Molinuevo, Jose Luis, van der Flier, Wiesje M. and Jessen, Frank (2019). Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimers. Dement., 15 (2). S. 185 - 194. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-5279

Full text not available from this repository.

Abstract

Introduction: Previous studies showed associations of brain volume differences and biomarker evidence for Alzheimer's disease (AD) in subjective cognitive decline (SCD). The consistency of this finding across SCD studies has not been investigated. Methods: We studied gray matter volume differences between SCD subjects with and without cerebrospinal fluid biomarker evidence for AD across three European memory clinic samples (German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia study, Amsterdam, Barcelona). Analysis of covariance models with samples and cerebrospinal fluid biomarkers as between-subject factors were calculated. Results: A significant main effect for AD biomarker (A beta(422)- > A beta(42)+) in the left medial temporal lobe (MTL) was found, with the absence of main effects for sample or interaction effects between AD biomarker and sample. This indicates consistent lower left MTL volume across three samples in SCD subjects with abnormal A beta(42) levels. Discussion: Our results support the model that in the presence of AD pathology, SCD corresponds to the late preclinical stage (stage 2 of AD) with smaller MTL volumes. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Teunissen, Charlotte E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Siyao UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED orcid.org/0000-0001-7596-0979 UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Verfaillie, Sander C. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barkhof, Frederik UNSPECIFIED orcid.org/0000-0003-3543-3706 UNSPECIFIED Coll-Padros, Nina UNSPECIFIED orcid.org/0000-0002-9282-6701 UNSPECIFIED Rami, Lorena UNSPECIFIED UNSPECIFIED UNSPECIFIED Molinuevo, Jose Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Flier, Wiesje M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158035
DOI:	10.1016/j.jalz.2018.09.002
Journal or Publication Title:	Alzheimers. Dement.
Volume:	15
Number:	2
Page Range:	S. 185 - 194
Date:	2019
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1552-5279
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMYLOID DEPOSITION; EPISODIC MEMORY; OLDER-ADULTS; DEPRESSION SCALE; MILD; BETA; IMPAIRMENT; DEMENTIA; ASSOCIATION; PREVENTION Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15803