Universität zu Köln

Wessels, Helen, Wagner, Michael ORCID: 0000-0003-2589-6440, Kuhr, Kathrin, Berning, Julia, Puetzfeld, Verena, Janssen, Birgit, Bottlender, Ronald, Maurer, Kurt, Moeller, Hans-Juergen, Gaebel, Wolfgang, Haefner, Heinz, Maier, Wolfgang, Klosterkoetter, Joachim and Bechdolf, Andreas (2019). Predictors of treatment response to psychological interventions in people at clinical high risk of first-episode psychosis. Early Interv. Psychiatry, 13 (1). S. 120 - 128. HOBOKEN: WILEY. ISSN 1751-7893

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Abstract

Aim Psychological interventions, such as cognitive behavioural therapy (CBT) and supportive counselling (SC), are used to treat people with schizophrenia and people at clinical high risk (CHR) of psychosis. However, little information is available on predictors of treatment response. This study aims to identify such predictors of psychological interventions in CHR. Methods A total of 128 help-seeking CHR outpatients were randomized into two groups-integrated psychological intervention (IPI), including CBT, and SC-for 12 months. Multiple regression analysis was used to identify demographic, symptomatic and functional variables that predict improvement in positive (PANSS Positive), negative (PANSS Negative) and basic symptoms (Basic symptom total score) and improvement in functioning (GAF) at 1-year follow up. Results In the merged group (IPI + SC), people who lived independently, were younger and presented with higher baseline functioning showed more improvement in symptomatic outcomes at follow up. Negative symptoms at baseline predicted less improvement in positive and basic symptoms. Being married or cohabiting and living in the primary family were found to correlate with good functioning at 1-year follow up. Conclusions Younger CHR individuals and those who are functioning well may particularly benefit from early intervention. Treatment might need to be modified for low-functioning CHR and those who already display higher scores of negative symptoms. Registration number: NCT00204087

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wessels, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Kuhr, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Berning, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Puetzfeld, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Janssen, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Bottlender, Ronald UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Haefner, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158576
DOI:	10.1111/eip.12460
Journal or Publication Title:	Early Interv. Psychiatry
Volume:	13
Number:	1
Page Range:	S. 120 - 128
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1751-7893
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE-BEHAVIOR THERAPY; 1ST EPISODE; SCHIZOPHRENIA; TRIAL; SYMPTOMS; METAANALYSIS; INDIVIDUALS; PREVENTION; RESISTANT; EFFICACY Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15857