Jensen, Poul Erik H., Warnke, Clemens, Ingenhoven, Kathleen, Piccoli, Luca ORCID: 0000-0002-1085-6502, Gasis, Marcia, Hermanrud, Christina, Fernandez-Rodriguez, Blanca M., Ryner, Malin, Kramer, Daniel, Link, Jenny, Ramanujam, Ryan, Auer, Michael, Buck, Dorothea, Grummel, Verena, Bertotti, Elisa, Fissolo, Nicolas ORCID: 0000-0002-7701-9346, Oliver-Martos, Begona, Nytrova, Petra, Khalil, Michael, Guger, Michael, Rathmaier, Sandra, Sievers-Stober, Claudia, Lindberg, Raija L. P., Hassler, Signe, Bachelet, Delphine, Aktas, Orhan ORCID: 0000-0002-2020-9210, Donnellan, Naoimh, Lawton, Andy, Hemmer, Bernhard, Havrdova, Eva Kubala, Kieseier, Bernd, Hartung, Hans-Peter, Comabella, Manuel, Montalban, Xavier ORCID: 0000-0002-0098-9918, Derfuss, Tobias, Sellebjerg, Finn ORCID: 0000-0002-1333-9623, Donnes, Pierre ORCID: 0000-0002-4613-2952, Pallardy, Marc, Spindeldreher, Sebastian, Broet, Philippe, Deisenhammer, Florian, Fogdell-Hahn, Anna ORCID: 0000-0002-0311-9184 and Sorensen, Per Soelberg ORCID: 0000-0002-2818-3780 (2019). Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study. J. Neuroimmunol., 326. S. 19 - 28. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-8421

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Abstract

Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-beta) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-beta-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-beta ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jensen, Poul Erik H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingenhoven, KathleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piccoli, LucaUNSPECIFIEDorcid.org/0000-0002-1085-6502UNSPECIFIED
Gasis, MarciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermanrud, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Rodriguez, Blanca M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryner, MalinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramer, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Link, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramanujam, RyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buck, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grummel, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertotti, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fissolo, NicolasUNSPECIFIEDorcid.org/0000-0002-7701-9346UNSPECIFIED
Oliver-Martos, BegonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nytrova, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khalil, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guger, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rathmaier, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sievers-Stober, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindberg, Raija L. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hassler, SigneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachelet, DelphineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aktas, OrhanUNSPECIFIEDorcid.org/0000-0002-2020-9210UNSPECIFIED
Donnellan, NaoimhUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawton, AndyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Havrdova, Eva KubalaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kieseier, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartung, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Comabella, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montalban, XavierUNSPECIFIEDorcid.org/0000-0002-0098-9918UNSPECIFIED
Derfuss, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sellebjerg, FinnUNSPECIFIEDorcid.org/0000-0002-1333-9623UNSPECIFIED
Donnes, PierreUNSPECIFIEDorcid.org/0000-0002-4613-2952UNSPECIFIED
Pallardy, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spindeldreher, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broet, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deisenhammer, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fogdell-Hahn, AnnaUNSPECIFIEDorcid.org/0000-0002-0311-9184UNSPECIFIED
Sorensen, Per SoelbergUNSPECIFIEDorcid.org/0000-0002-2818-3780UNSPECIFIED
URN: urn:nbn:de:hbz:38-159249
DOI: 10.1016/j.jneuroim.2018.11.002
Journal or Publication Title: J. Neuroimmunol.
Volume: 326
Page Range: S. 19 - 28
Date: 2019
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1872-8421
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IFN-BETA; CLINICAL-USE; THERAPY; BINDING; RECOMMENDATIONS; IMMUNOGENICITY; IFN-BETA-1A; VALIDATION; ASSAYMultiple languages
Immunology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15924

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