Universität zu Köln

Liao, Yupeng, Oros-Peusquens, Ana-Maria, Lindemeyer, Johannes ORCID: 0000-0003-4756-7947, Lechea, Nazim, Weiss-Lucas, Carolin, Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Shah, N. Jon ORCID: 0000-0002-8151-6169 (2019). An MR technique for simultaneous quantitative imaging of water content, conductivity and susceptibility, with application to brain tumours using a 3T hybrid MR-PET scanner. Sci Rep, 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Approaches for the quantitative mapping of water content, electrical conductivity and susceptibility have been developed independently. The purpose of this study is to develop a method for simultaneously acquiring quantitative water content, electrical conductivity and susceptibility maps based on a 2D multi-echo gradient echo sequence. Another purpose is to investigate the changes in these properties caused by brain tumours. This was done using a 3T hybrid magnetic resonance imaging and positron emission tomography (MR-PET) scanner. Water content maps were derived after performing T-2* and transmit-receive field bias corrections to magnitude images essentially reflecting only the H2O content contrast. Phase evolution during the multi-echo train was used to generate field maps and derive quantitative susceptibility, while the conductivity maps were retrieved from the phase value at zero echo time. Performance of the method is demonstrated on phantoms and two healthy volunteers. In addition, the method was applied to three patients with brain tumours and a comparison to maps obtained from PET using O-(2-[18F]fluoroethyl)-L-tyrosine and clinical MR images is presented. The combined information of the water content, conductivity and susceptibility may provide additional information about the tissue viability. Future studies can benefit from the evaluation of these contrasts with shortened acquisition times.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liao, Yupeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Oros-Peusquens, Ana-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindemeyer, Johannes UNSPECIFIED orcid.org/0000-0003-4756-7947 UNSPECIFIED Lechea, Nazim UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss-Lucas, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159299
DOI:	10.1038/s41598-018-36435-8
Journal or Publication Title:	Sci Rep
Volume:	9
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VIVO CONDUCTIVITY; MAGNETIC-FIELD; TOMOGRAPHY; VALIDATION; IRON; AGE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15929