Universität zu Köln

Sun, Yu, Bi, Qiuhui, Wang, Xiaoni, Hu, Xiaochen, Li, Huijie, Li, Xiaobo, Ma, Ting, Lu, Jie, Chan, Piu, Shu, Ni and Han, Ying (2019). Prediction of Conversion From Amnestic Mild Cognitive Impairment to Alzheimer's Disease Based on the Brain Structural Connectome. Front. Neurol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-2295

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Abstract

Background: Early prediction of disease progression in patients with amnestic mild cognitive impairment (aMCI) is important for early diagnosis and intervention of Alzheimer's disease (AD). Previous brain network studies have suggested topological disruptions of the brain connectome in aMCI patients. However, whether brain connectome markers at baseline can predict longitudinal conversion from aMCI to AD remains largely unknown. Methods: In this study, 52 patients with aMCI and 26 demographically matched healthy controls from a longitudinal cohort were evaluated. During 2 years of follow-up, 26 patients with aMCI were retrospectively classified as aMCI converters and 26 patients remained stable as aMCI non-converters based on whether they were subsequently diagnosed with AD. For each participant, diffusion tensor imaging at baseline and deterministic tractography were used to map the whole-brain white matter structural connectome. Graph theoretical analysis was applied to investigate the convergent and divergent connectivity patterns of structural connectome between aMCI converters and non-converters. Results: Disrupted topological organization of the brain structural connectome were identified in both aMCI converters and non-converters. More severe disruptions of structural connectivity in aMCI converters compared with non-converters were found, especially in the default-mode network regions and connections. Finally, a support vector machine-based classification demonstrated the good discriminative ability of structural connectivity in differentiating aMCI patients from controls with an accuracy of 98%, and in discriminating converters from non-converters with an accuracy of 81%. Conclusion: Our study provides potential structural connectome/connectivity-based biomarkers for predicting disease progression in aMCI, which is important for the early diagnosis of AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sun, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Bi, Qiuhui UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Huijie UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xiaobo UNSPECIFIED UNSPECIFIED UNSPECIFIED Ma, Ting UNSPECIFIED UNSPECIFIED UNSPECIFIED Lu, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Chan, Piu UNSPECIFIED UNSPECIFIED UNSPECIFIED Shu, Ni UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159379
DOI:	10.3389/fneur.2018.01178
Journal or Publication Title:	Front. Neurol.
Volume:	9
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-2295
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; TEMPORAL-LOBE ATROPHY; WHITE-MATTER; FUNCTIONAL CONNECTIVITY; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; TOPOLOGICAL ORGANIZATION; NETWORK TOPOLOGY; DEMENTIA Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15937