Universität zu Köln

Chen, Guanqun ORCID: 0000-0002-8133-834X, Yang, Kun, Du, Wenying, Hu, Xiaochen and Han, Ying (2019). Clinical Characteristics in Subjective Cognitive Decline with and without Worry: Baseline Investigation of the SILCODE Study. J. Alzheimers Dis., 72 (2). S. 443 - 455. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Subjective cognitive decline (SCD) refers to the self-perception of cognitive decline among cognitively normal elderly individuals. SCD related worry confers a higher risk of developing cognitive decline. However, the clinical characteristics of SCD patients with worry are not clear. Objective: To explore the clinical characteristics of SCD patients with worry. Methods: A cross-sectional study was carried out, with 270 consecutive participants of the Sino Longitudinal Study on Cognitive Decline (SILCODE) study. Participants were classified as normal controls (n = 36), SCD patients without worry (n = 91), or SCD patients with worry (n = 143) and were comprehensively compared on 1) their self-perception of cognitive decline, 2) multiple cognitive domains, 3) neuropsychiatric symptoms, and 4) sleep status. Results: SCD patients with worry had significantly more self-perception of cognitive decline (p < 0.001); increased depression (p < 0.001) and anxiety (p < 0.001); decreased sleep quality (p < 0.001), sleep latency (p < 0.05), sleep time (p < 0.01), and sleep efficiency (p < 0.05); more sleep disorders (p < 0.05) and daytime dysfunction (p < 0.05); and a higher global score on the Pittsburgh Sleep Quality Index (p < 0.001) than normal controls. Although there was a significant increase only in self-perception of cognitive decline (p < 0.001), anxiety (p < 0.001), and Pittsburgh Sleep Quality Index scores (p < 0.05), the severity of the increase in those without worry was between that in SCD patients with worry and normal controls. Conclusion: Our findings show that participants who had SCD with worry showed distinct clinical characteristics compared with normal controls and SCD patients without worry, which could be useful for understanding the higher risk in SCD patients with worry of subsequently developing Alzheimer's disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chen, Guanqun UNSPECIFIED orcid.org/0000-0002-8133-834X UNSPECIFIED Yang, Kun UNSPECIFIED UNSPECIFIED UNSPECIFIED Du, Wenying UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160355
DOI:	10.3233/JAD-190501
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	72
Number:	2
Page Range:	S. 443 - 455
Date:	2019
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRECLINICAL ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; DEPRESSIVE SYMPTOMS; DAYTIME SLEEPINESS; AMYLOID-BETA; MILD; IMPAIRMENT; RISK; MEMORY; ASSOCIATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16035