Universität zu Köln

Matthaei, Mario, Hribek, Agathe, Clahsen, Thomas, Bachmann, Bjoern, Cursiefen, Claus and Jun, Albert S. (2019). Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects. In: Annual Review of Vision Science, S. 151 - 176. PALO ALTO: ANNUAL REVIEWS.

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Abstract

Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial disorder and the most common cause of corneal transplantation worldwide. Professor Ernst Fuchs described the first 13 cases of FECD more than 100 years ago. Since then, we have seen far-reaching progress in its diagnosis and treatment. In the field of diagnostics, new technologies enable the development of more accurate classification systems and the more detailed breakdown of the genetic basis of FECD. Laboratory studies help in deciphering the molecular pathomechanisms. The development of minimally invasive surgical techniques leads to a continuous improvement of the postoperative result. This review highlights and discusses clinical, genetic, pathophysiologic, and therapeutic aspects of this common and important corneal disorder.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Hribek, Agathe UNSPECIFIED UNSPECIFIED UNSPECIFIED Clahsen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Jun, Albert S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160573
DOI:	10.1146/annurev-vision-091718-014852
Title of Book:	Annual Review of Vision Science
Volume:	5
Page Range:	S. 151 - 176
Date:	2019
Publisher:	ANNUAL REVIEWS
Place of Publication:	PALO ALTO
ISSN:	2374-4650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNFOLDED PROTEIN RESPONSE; TRINUCLEOTIDE REPEAT EXPANSION; DESCEMET MEMBRANE; EXTRACELLULAR-MATRIX; MOUSE MODEL; CATARACT-SURGERY; CELL SURVIVAL; TCF4 GENE; IN-VITRO; PENETRATING KERATOPLASTY Multiple languages Neurosciences; Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16057