Universität zu Köln

Achilles, Elisabeth I. S., Ballweg, Charlotta S., Niessen, Eva ORCID: 0000-0002-2801-0986, Kusch, Mona, Ant, Jana M., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2019). Neural correlates of differential finger gesture imitation deficits in left hemisphere stroke. NeuroImage-Clin., 23. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Behavioural studies in apraxic patients revealed dissociations between the processing of meaningful (MF) and meaningless (ML) gestures. Consequently, the existence of two differential neural mechanisms for the imitation of either gesture type has been postulated. While the indirect (semantic) route exclusively enables the imitation of MF gestures, the direct route can be used for the imitation of any gesture type, irrespective of meaning, and thus especially for ML gestures. Concerning neural correlates, it is debated which of the visuo-motor streams (i.e., the ventral steam, the ventro-dorsal stream, or the dorso-dorsal stream) supports the postulated indirect and direct imitation routes. To probe the hypotheses that regions of the dorso-dorsal stream are involved differentially in the imitation of ML gestures and that regions of the ventro-dorsal stream are involved differentially in the imitation of MF gestures, we analysed behavioural (imitation of MF and ML finger gestures) and lesion data of 293 patients with a left hemisphere (LH) stroke. Confirming previous work, the current sample of LH stroke patients imitated MF finger gestures better than ML finger gestures. The analysis using voxel-based lesion symptom mapping (VLSM) revealed that LH damage to dorso-dorsal stream areas was associated with an impaired imitation of ML finger gestures, whereas damage to ventro-dorsal regions was associated with a deficient imitation of MF finger gestures. Accordingly, the analyses of the imitation of visually uniform and thus highly comparable MF and ML finger gestures support the dual-route model for gesture imitation at the behavioural and lesion level in a substantial patient sample. Furthermore, the data show that the direct route for ML finger gesture imitation depends on the dorso-dorsal visuo-motor stream while the indirect route for MF finger gesture imitation is related to regions of the ventro-dorsal visuo-motor stream.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Achilles, Elisabeth I. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ballweg, Charlotta S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Eva UNSPECIFIED orcid.org/0000-0002-2801-0986 UNSPECIFIED Kusch, Mona UNSPECIFIED UNSPECIFIED UNSPECIFIED Ant, Jana M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160620
DOI:	10.1016/j.nicl.2019.101915
Journal or Publication Title:	NeuroImage-Clin.
Volume:	23
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR PARIETAL CORTEX; CRITICAL BRAIN-REGIONS; STRATEGIC CONTROL; MULTIPLE ROUTES; LESION; APRAXIA; STREAMS; DORSAL; DAMAGE; MEANINGFUL Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16062