Universität zu Köln

Neundorf, Ines ORCID: 0000-0001-6450-3991 (2019). Antimicrobial and Cell-Penetrating Peptides: How to Understand Two Distinct Functions Despite Similar Physicochemical Properties. In: Advances in Experimental Medicine and Biology, S. 93 - 110. SINGAPORE: SPRINGER-VERLAG SINGAPORE PTE LTD. ISBN 978-981-13-3588-4; 978-981-13-3587-7

Full text not available from this repository.

Abstract

Antimicrobial and cell-penetrating peptides are both classes of membrane-active peptides sharing similar physicochemical properties. Both kinds of peptides have attracted much attention owing to their specific features. AMPs disrupt cell membranes of bacteria and display urgently needed antibiotic substances with alternative modes of action. Since the multidrug resistance of bacterial pathogens is a more and more raising concern, AMPs have gained much interest during the past years. On the other side, CPPs enter eukaryotic cells without substantially affecting the plasma membrane. They can be used as drug delivery platforms and have proven their usefulness in various applications. However, although both groups of peptides are quite similar, their intrinsic activity is often different, and responsible factors are still in discussion. The aim of this chapter is to summarize and shed light on recent findings and concepts dealing with differences and similarities of AMPs and CPPs and to understand these different functions.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-160979
DOI:	10.1007/978-981-13-3588-4_7
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	1117
Page Range:	S. 93 - 110
Date:	2019
Publisher:	SPRINGER-VERLAG SINGAPORE PTE LTD
Place of Publication:	SINGAPORE
ISSN:	2214-8019
ISBN:	978-981-13-3588-4; 978-981-13-3587-7
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARAN-SULFATE; ACTIVE PEPTIDES; LYTIC PEPTIDES; MEMBRANE; TRANSLOCATION; SURFACE; CHOLESTEROL; ORGANIZATION; STRATEGIES; TRYPTOPHAN Multiple languages Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16097