Universität zu Köln

Hammes, Jochen, Hohberg, Melanie, Taeger, Philipp, Wild, Markus, Zlatopolskiy, Boris ORCID: 0000-0001-5818-1260, Krapf, Philipp ORCID: 0000-0003-1671-2443, Neumaier, Bernd, Schoemacker, Klaus, Kobe, Carsten, Schmidt, Matthias, Dietlein, Markus and Drzezga, Alexander ORCID: 0000-0001-6018-716X (2018). Uptake in non-affected bone tissue does not differ between [F-18]-DCFPyL and [Ga-68]-HBED-CC PSMA PET/CT. PLoS One, 13 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Introduction [Ga-68]PSMA-HBED-CC and [F-18]DCFPyL show a high potential for the detection of recurrent prostate cancer. While F-18-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [F-18]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68 Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal. Methods A comparison of average bone SUV was performed in 17 bone-negative and 4 bone-positive patients. All patients underwent PET/CT 125 minutes after application of [F-18]DCFPyL and 73 minutes after application of [Ga-68]PSMA-HBED-CC at another date. Results Native SUVs in unaffected bone tissue and SUVs relative to liver uptake were lower in [F-18] DCFPyL (0.49) than in [Ga-68]PSMA-HBED-CC scans (0.52). SUVs relative to gluteal muscles did not differ between the two tracers. Average lesional SUVs did not differ between tracers. Conclusion No difference of average bone signal intensity was observed for [F-18]DCFPyL-PET/CT in comparison to [Ga-68]PSMA-HBED-CC scans indicating that diagnostic assessment of the skeleton is not affected by non-specific accumulation of free [F-18]fluoride or 68 Ga.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohberg, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Taeger, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zlatopolskiy, Boris UNSPECIFIED orcid.org/0000-0001-5818-1260 UNSPECIFIED Krapf, Philipp UNSPECIFIED orcid.org/0000-0003-1671-2443 UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemacker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-161828
DOI:	10.1371/journal.pone.0209613
Journal or Publication Title:	PLoS One
Volume:	13
Number:	12
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VIVO; PROSTATE; F-18 Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16182