Zeka, Fjoralba, Decock, Anneleen ORCID: 0000-0002-1091-0927, Van Goethem, Alan, Vanderheyden, Katrien ORCID: 0000-0001-5934-0366, Demuynck, Fleur, Lammens, Tim, Helsmoortel, Hetty H., Vermeulen, Joelle, Noguera, Rosa, Berbegall, Ana P., Combaret, Valerie, Schleiermacher, Gudrun, Laureys, Genevieve, Schramm, Alexander, Schulte, Johannes H., Rahman, Sven, Bienertova-Vasku, Julie, Mazanek, Pavel, Jeison, Marta, Ash, Shifra, Hogarty, Michael D., Moreno-Smith, Mirthala, Barbieri, Eveline, Shohet, Jason, Berthold, Frank, Van Maerken, Tom, Speleman, Frank, Fischer, Matthias, De Preter, Katleen, Mestdagh, Pieter and Vandesompele, Jo (2018). Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients. JCI Insight, 3 (23). ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 2379-3708

Full text not available from this repository.

Abstract

In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed for identification of noninvasive biomarkers with potential in monitoring metastatic disease, After determining the circulating neuroblastoma miRNome, 743 miRNAs were screened in 2 independent cohorts of 131 and 54 patients. Evaluation of serum miRNA variance in a model testing for tumor stage, MYCN status, age at diagnosis, and overall survival revealed tumor stage as the most significant factor impacting miRNA abundance in neuroblastoma serum. Differential abundance analysis between patients with metastatic and localized disease revealed 9 miRNAs strongly associated with metastatic stage 4 disease in both patient cohorts. Increasing levels of these miRNAs were also observed in serum from xenografted mice bearing human neuroblastoma tumors. Moreover, murine serum miRNA levels were strongly associated with tumor volume. These findings were validated in longitudinal serum samples from metastatic neuroblastoma patients, where the 9 miRNAs were associated with disease burden and treatment response.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zeka, FjoralbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Decock, AnneleenUNSPECIFIEDorcid.org/0000-0002-1091-0927UNSPECIFIED
Van Goethem, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanderheyden, KatrienUNSPECIFIEDorcid.org/0000-0001-5934-0366UNSPECIFIED
Demuynck, FleurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammens, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helsmoortel, Hetty H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vermeulen, JoelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noguera, RosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berbegall, Ana P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Combaret, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schleiermacher, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laureys, GenevieveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schramm, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, Johannes H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahman, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bienertova-Vasku, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazanek, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeison, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ash, ShifraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogarty, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreno-Smith, MirthalaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbieri, EvelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shohet, JasonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthold, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Maerken, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Speleman, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Preter, KatleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mestdagh, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandesompele, JoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-162381
DOI: 10.1172/jci.insight.97021
Journal or Publication Title: JCI Insight
Volume: 3
Number: 23
Date: 2018
Publisher: AMER SOC CLINICAL INVESTIGATION INC
Place of Publication: ANN ARBOR
ISSN: 2379-3708
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SERUM; EXPRESSION; DNA; CHILDHOOD; QUALITYMultiple languages
Medicine, Research & ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16238

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item