Universität zu Köln

Olschewski, Andrea, Berghausen, Eva M., Eichstaedt, Christina A., Fleischmann, Bernd K., Gruenig, Ekkehard, Gruenig, Gabriele, Hansmann, Georg ORCID: 0000-0003-0709-3935, Harbaum, Lars, Hennigs, Jan K. ORCID: 0000-0002-7784-8267, Jonigk, Danny, Kuebler, Wolfgang M., Kwapiszewska, Grazyna, Pullamsetti, Soni S., Stacher, Elvira, Weissmann, Norbert, Wenzel, Daniela ORCID: 0000-0003-1100-6363 and Schermuly, Ralph T. (2018). Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018. Int. J. Cardiol., 272. S. 4 - 11. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy. In addition to new insights in the pathobiology of this disease, this working group of the Cologne Consensus Conference also highlights novel concepts and potential new therapeutic targets to further improve the treatment options in PAH. (c) 2018 Published by Elsevier B.V.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Olschewski, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Berghausen, Eva M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichstaedt, Christina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleischmann, Bernd K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenig, Ekkehard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenig, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansmann, Georg UNSPECIFIED orcid.org/0000-0003-0709-3935 UNSPECIFIED Harbaum, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennigs, Jan K. UNSPECIFIED orcid.org/0000-0002-7784-8267 UNSPECIFIED Jonigk, Danny UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuebler, Wolfgang M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kwapiszewska, Grazyna UNSPECIFIED UNSPECIFIED UNSPECIFIED Pullamsetti, Soni S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stacher, Elvira UNSPECIFIED UNSPECIFIED UNSPECIFIED Weissmann, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Daniela UNSPECIFIED orcid.org/0000-0003-1100-6363 UNSPECIFIED Schermuly, Ralph T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162536
DOI:	10.1016/j.ijcard.2018.09.070
Journal or Publication Title:	Int. J. Cardiol.
Volume:	272
Page Range:	S. 4 - 11
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARTERIAL-HYPERTENSION; RIGHT VENTRICLE; ION CHANNELS; HUMAN LUNG; VASOCONSTRICTION; HYPOXIA; CONTRIBUTES; PROGRESSION; ACTIVATION; MECHANISMS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16253