Zhao, Yue, Dong, Qiongzhu, Li, Jiahui, Zhang, Kaili, Qin, Jie, Zhao, Jiangang, Sun, Qiye, Wang, Zhefang ORCID: 0000-0002-2297-2586, Wartmann, Thomas, Jauch, Karl Walter, Nelson, Peter J., Qin, LunXiu and Bruns, Christiane (2018). Targeting cancer stem cells and their niche: perspectives for future therapeutic targets and strategies. Semin. Cancer Biol., 53. S. 139 - 156. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1096-3650

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Abstract

A small subpopulation of cells within the bulk of tumors share features with somatic stem cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to conventional therapy. These cells have been referred to as cancer stem cells (CSCs). Recent reports support the central importance of a cancer stem cell-like niche that appears to help foster the generation and maintenance of CSCs. In response to signals provided by this microenvironment, CSCs express the tumorigenic characteristics that can drive tumor metastasis by the induction of epithelial-mesenchymal-transition (EMT) that in turn fosters the migration and recolonization of the cells as secondary tumors within metastatic niches. We summarize here recent advances in cancer stem cell research including the characterization of their genetic and epigenetic features, metabolic specialities, and crosstalk with aging-associated processes. Potential strategies for targeting CSCs, and their niche, by regulating CSCs plasticity, or therapeutic sensitivity is discussed. Finally, it is hoped that new strategies and related therapeutic approaches as outlined here may help prevent the formation of the metastatic niche, as well as counter tumor progression and metastatic growth.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zhao, YueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dong, QiongzhuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, JiahuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, KailiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qin, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, JiangangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, QiyeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, ZhefangUNSPECIFIEDorcid.org/0000-0002-2297-2586UNSPECIFIED
Wartmann, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jauch, Karl WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, Peter J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qin, LunXiuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-163140
DOI: 10.1016/j.semcancer.2018.08.002
Journal or Publication Title: Semin. Cancer Biol.
Volume: 53
Page Range: S. 139 - 156
Date: 2018
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication: LONDON
ISSN: 1096-3650
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PHASE-I TRIAL; PANCREATIC-CANCER; PROSTATE-CANCER; METABOLIC-REGULATION; COLORECTAL-CANCER; OPEN-LABEL; OXIDATIVE-PHOSPHORYLATION; DARATUMUMAB MONOTHERAPY; CHEMOTHERAPY RESISTANCE; ENDOTHELIAL-CELLSMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16314

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