Universität zu Köln

Fiess, Achim, Koelb-Keerl, Ruth, Schuster, Alexander K., Knuf, Markus, Kirchhof, Bernd, Muether, Philipp S. and Bauer, Jacqueline (2018). Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4-10 years. Acta Ophthalmol., 96 (8). S. E1010 - 8. HOBOKEN: WILEY. ISSN 1755-3768

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Abstract

Purpose The objective of this study was to investigate the relationship between visual acuity, peripapillary retinal nerve fibre layer (pRNFL), retinal thickness at the fovea and other factors with the neurologic status of former preterm children. Methods Results In this cross-sectional hospital based study in a maximum care tertiary centre, detailed anthropometric and ophthalmological data of former preterm children ranging from 4 to 10 years of age with a gestational age (GA) <= 32 weeks were assessed. Analyses of the correlation between pRNFL and foveal thickness, as well as visual acuity (VA) parameters at 4-10 years of age, with neurological development were evaluated at 2 years of age by Bayley Scales II of Infant Development, including Psychomotor Developmental Index (PDI) and Mental Developmental Index (MDI). Data were available for 106 former preterm children. Univariate analysis revealed a correlation between PDI with pRNFL thickness (B = 0.43; p = 0.013), VA (B = -29.2; p < 0.001), GA (B = 2.7; p = 0.002), retinopathy of prematurity (ROP; B = -16.3; p < 0.001) and intraventricular haemorrhages (IVH; B = -22.9; p < 0.001) but not with strabismus or foveal thickness. In the multivariable analysis, the association remained for visual acuity and IVH, but not for pRNFL thickness or ROP. Mental Developmental Index (MDI) was associated with visual acuity (B = -34.3; p = 0.001), GA (B = 2.53; p = 0.02) and IVH (B = -15.4; p = 0.02), the latter also in the multivariable analysis. Conclusion This study revealed an association between PDI at 2 years of age and lower visual acuity later in childhood. However, there was no correlation between retinal morphology and neurologic outcome in former preterm children after adjusting for several potential confounders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fiess, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Koelb-Keerl, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuster, Alexander K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163397
DOI:	10.1111/aos.13755
Journal or Publication Title:	Acta Ophthalmol.
Volume:	96
Number:	8
Page Range:	S. E1010 - 8
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NERVE-FIBER LAYER; TERM INFANTS; BIRTH-WEIGHT; PREMATURE-INFANTS; THICKNESS; OUTCOMES; RETINOPATHY; IMPAIRMENT; GROWTH; BORN Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16339