Universität zu Köln

Vettermann, Franziska J., Felsberg, Joerg, Reifenberger, Guido, Hasselblatt, Martin, Forbrig, Robert, Berding, Georg, la Fougere, Christian, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Schittenhelm, Jens, Weis, Joachim, Albert, Nathalie L. and Schueller, Ulrich (2018). Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET. Clin. Nucl. Med., 43 (12). S. 895 - 899. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0229

Full text not available from this repository.

Abstract

Background Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-18-FET PET in H3-G34-mutant gliomas are unknown. Methods We report on MRI and F-18-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-18-FET PET characteristics were evaluated on the basis of static F-18-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-18-FET PET data. Results MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-18-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes. Conclusions MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-18-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vettermann, Franziska J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Felsberg, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Reifenberger, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasselblatt, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Forbrig, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Berding, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED la Fougere, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Schittenhelm, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Weis, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Albert, Nathalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schueller, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163577
DOI:	10.1097/RLU.0000000000002300
Journal or Publication Title:	Clin. Nucl. Med.
Volume:	43
Number:	12
Page Range:	S. 895 - 899
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-0229
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language F-18-FET PET; HIGH-GRADE; BRAIN-TUMORS; PERFORMANCE; CHILDREN; NEED Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16357