Universität zu Köln

Hammes, Jochen, Drzezga, Alexander and van Eimeren, Thilo (2018). The Role of Tau Imaging in Parkinsonian Disorders. Curr. Neurol. Neurosci. Rep., 18 (12). NEW YORK: SPRINGER. ISSN 1534-6293

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Abstract

Purpose of ReviewDifferential diagnosis of atypical Parkinson syndromes (APS) is difficult as clinical presentations may vary and as there is a strong overlap between disease entities. Aggregations of misfolded and hyperphosphorylated tau proteins are the common denominator of many of these diseases.Recent FindingsSeveral tau targeting positron emission tomography (PET) tracers have been evaluated as possible biomarkers in APS in the recent years. For Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration, promising results have been reported with regard to the ability to detect the presence of disease and to discriminate patients from controls. However, the discussion about the specificity of the first-generation radiotracers and their value in the clinical context is ongoing.SummaryA combined interpretation of signal strength and distribution pattern in PET scans with first- and second-generation tracers may be helpful in clinical diagnosis and follow-up of patients with APS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163604
DOI:	10.1007/s11910-018-0898-3
Journal or Publication Title:	Curr. Neurol. Neurosci. Rep.
Volume:	18
Number:	12
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1534-6293
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; DISEASE DEMENTIA; LEWY BODIES; F-18-AV-1451; BINDING; PET; DIAGNOSIS; NEUROPATHOLOGY Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16360