Universität zu Köln

Tribius, S., Wuerdemann, N., Laban, S., Sharma, S. J., Wagner, S., Hoffmann, T. K., Wittekindt, C. and Klussmann, J. P. (2018). Update on HPV-associated head and neck cancer-highlights of the 2018 ASCO Annual Meeting. HNO, 66 (12). S. 888 - 896. NEW YORK: SPRINGER. ISSN 1433-0458

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Abstract

Rising incidence rates in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and a significantly improved prognosis have brought this entity into scientific focus. At this year's American Society of Clinical Oncology (ASCO) Annual Meeting, 291 studies with the keyword HPV were presented, the majority of which were in head and neck cancer. Due to high rates of late toxicities after conventional therapy, de-intensified treatment concepts are being increasingly discussed, although data from prospective phase III studies were not presented. Retrospective data on the latest TNM staging (downstaging in many HPV-associated patients) and other risk stratification systems were presented. HPV diagnostics based solely on p16 immunohistochemistry were discussed. Many groups presented work on the HPV association and its prognostic relevance not only in oropharyngeal carcinoma, but also in oral cavity, hypopharyngeal, and locally advanced laryngeal squamous cell carcinoma. New prognostic biomarkers such as methylation signatures appear to be promising. New data suggest equal survival rates in HPV-associated stage I OPSCC treated with surgery alone in comparison to patients who received adjuvant therapy after surgery. A possible negative effect on overall survival in stage III HPV-associated OPSCC with a cisplatin dose <= 200mg/m(2) was discussed. Results of deescalation studies are urgently awaited, in order to be able to treat HPV-associated OPSCC patients as precisely and as specifically as possible and ensure long-term quality of life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tribius, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuerdemann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laban, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, T. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittekindt, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163822
DOI:	10.1007/s00106-018-0577-3
Journal or Publication Title:	HNO
Volume:	66
Number:	12
Page Range:	S. 888 - 896
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0458
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIGNATURE PREDICTS SURVIVAL; HUMAN-PAPILLOMAVIRUS; 8TH EDITION Multiple languages Otorhinolaryngology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16382