Universität zu Köln

Martini, Thomas, Heinkele, Jakob, Mayr, Roman, Weis, Cleo-Aron, Wezel, Felix, Wahby, Sarah, Eckstein, Markus, Schnoller, Thomas, Breyer, Johannes, Wirtz, Ralph, Ritter, Manuel, Bolenz, Christian and Erben, Philipp ORCID: 0000-0002-8279-7636 (2018). Predictive value of lymphangiogenesis and proliferation markers on mRNA level in urothelial carcinoma of the bladder after radical cystectomy. Urol. Oncol.-Semin. Orig. Investig., 36 (12). NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-2496

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Abstract

Objective: To evaluate the mRNA expression of lymphangiogenesis and proliferation markers and to examine its association with histopathological characteristics and clinical outcome in patients with urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC). Patients and methods: Gene expression analysis of the vascular endothelial growth-C and-D (VEGF-C/-D), its receptor VEGF receptor-3 (VEGFR-3), MKI67, and RACGAP1 was performed in 108 patients after radical cystectomy and their correlation with clinical-pathological parameters was investigated. Uni- and multivariate regression analyses were used to identify predictors for cancer -specific survival (CSS), recurrence-free survival (RFS) and overall survival (OS) after RC. Results: The expression of RACGAP1 and VEGFR-3 showed an association with a higher pT stage (P = 0.049; P = 0.009). MKI67 showed an association with a high-grade urothelial carcinoma of the bladder (P = 0.021). VEGFR-3 expression was significantly associated with the presence of lymphovascular invasion (LVI) (P = 0.016) and lymph node metastases (pN+) (P = 0.028). With the univariate analysis, overexpression of VEGFR-3 (P = 0.029) and the clinical-pathological parameters pT stage (P < 0.0001), pN+ (P = 0.0004), LVI (P < 0.0001) and female gender (P = 0.021) were significantly associated with a reduced CSS. Multivariate analysis identified a higher pT stage (P = 0.017) and LVI (P = 0.008) as independent predictors for reduced CSS. Independent predictors for reduced OS were a higher pT stage (P = 0.0007) and LVI (P = 0.0021), while overexpression of VEGF-D was associated with better OS (P < 0.0001). Conclusions: The mRNA expression of the investigated markers showed associations with common histopathological parameters. Increased expression of VEGF-D is independently associated with better overall survival. (C) 2018 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Martini, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinkele, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayr, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Weis, Cleo-Aron UNSPECIFIED UNSPECIFIED UNSPECIFIED Wezel, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahby, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckstein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnoller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Breyer, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolenz, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Erben, Philipp UNSPECIFIED orcid.org/0000-0002-8279-7636 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164462
DOI:	10.1016/j.urolonc.2018.09.003
Journal or Publication Title:	Urol. Oncol.-Semin. Orig. Investig.
Volume:	36
Number:	12
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-2496
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSITIONAL-CELL CARCINOMA; INDEPENDENT PREDICTOR; RACGAP1 EXPRESSION; CANCER PATIENTS; VEGF-D; KI67; NEOADJUVANT; RECURRENCE; MORTALITY; OUTCOMES Multiple languages Oncology; Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16446