Universität zu Köln

Schramm, Christoph, Kuetting, Fabian, Lang, Sonja, Kasper, Philipp, Chon, Seung-Hun ORCID: 0000-0002-8923-6428 and Steffen, Hans-Michael (2018). Hyperplastic polyps and nonadvanced adenomas, but not advanced polypoid lesions, are detected more frequently in the presence of colonic diverticula during screening colonoscopies. Z. Gastroent., 56 (12). S. 1475 - 1481. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-7803

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Abstract

Background Studies investigating the association between colonic diverticula and colorectal polyps and colorectal cancer (CRC) have reported conflicting results. We aimed to evaluate this association for all relevant different histological polyp subtypes (i.e., hyperplastic polyps [HPs], sessile and traditionally serrated adenomas, clinically relevant serrated polyps, nonadvanced and advanced adenomas) in an exclusive colonoscopy screening cohort. Material and methods We conducted a retrospective analysis of individuals >= 50 years of age with an average risk for CRC who underwent a screening colonoscopy between January 1, 2012, and December 14, 2016, at a tertiary academic hospital and 6 community-based private practices. Exclusion criteria were conditions with increased risk for CRC (e.g., inflammatory bowel disease, history of CRC, hereditary cancer syndromes), previous colonoscopy at the same institution, and incomplete procedures. Results A total of 4196 colonoscopies were included (mean age: 63.4, standard deviation: +/- 7.6 years, 48.6 % men). In the presence of colonic diverticula, significantly increased odds ratios (OR) were found for the detection of HPs overall (OR: 1.340, 95 % confidence interval [CI]: 1.133 - 1.584, p = 0.001) and in the distal colon (OR: 1.459, 95 % CI: 1.208 - 1.763, p < 0.001), as well as for nonadvanced adenomas (OR: 1.355, 95 % CI: 1.144 - 1.604, p < 0.001) in the distal colon after adjusting for age and gender. The mean numbers of different histological polyp subtypes detected per procedure with at least one of the histological polyp subtype did not differ between both groups. Conclusions Endoscopists should be vigilant for the detection of adenomatous polyps in the distal colon when diverticula are present during colonoscopy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schramm, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuetting, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasper, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Chon, Seung-Hun UNSPECIFIED orcid.org/0000-0002-8923-6428 UNSPECIFIED Steffen, Hans-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164527
DOI:	10.1055/a-0755-2448
Journal or Publication Title:	Z. Gastroent.
Volume:	56
Number:	12
Page Range:	S. 1475 - 1481
Date:	2018
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-7803
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLORECTAL NEOPLASIA; DIETARY FIBER; RISK-FACTORS; ASSOCIATION; PREVALENCE; GUIDELINES; DISEASE; CANCER; BOWEL Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16452