Kesch, Claudia, Radtke, Jan-Philipp, Wintsche, Axel, Wiesenfarth, Manuel, Luttje, Mariska, Gasch, Claudia, Dieffenbacher, Svenja, Pecqueux, Carine, Teber, Dogu, Hatiboglu, Gencay, Nyarangi-Dix, Joanne, Simpfendoerfer, Tobias, Schoenberg, Gita, Dimitrakopoulou-Strauss, Antonia ORCID: 0000-0003-0338-9472, Freitag, Martin, Duensing, Anette ORCID: 0000-0002-0168-4067, Gruellich, Carsten, Jaeger, Dirk, Goetz, Michael ORCID: 0000-0003-0984-224X, Grabe, Niels, Schweiger, Michal-Ruth, Pahernik, Sascha, Perner, Sven, Herpel, Esther, Roth, Wilfried, Wieczorek, Kathrin, Maier-Hein, Klaus, Debus, Jurgen, Haberkorn, Uwe, Giesel, Frederik, Galle, Joerg, Hadaschik, Boris ORCID: 0000-0002-1052-2692, Schlemmer, Heinz-Peter, Hohenfellner, Markus, Bonekamp, David, Sueltmann, Holger and Duensing, Stefan (2018). Correlation between genomic index lesions and mpMRI and Ga-68-PSMA-PET/CT imaging features in primary prostate cancer. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether and to what extent lesions detected by these imaging techniques correlate with genomic features of PCa. The aim of this study was therefore to define a genomic index lesion based on chromosomal copy number alterations (CNAs) as marker for tumor aggressiveness in prostate biopsies in direct correlation to multiparametric (mp) MRI and Ga-68-PSMA-PET/CT imaging features. CNA profiles of 46 biopsies from five consecutive patients with clinically high-risk PCa were obtained from radiologically suspicious and unsuspicious areas. All patients underwent mpMRI, MRI/TRUS-fusion biopsy, Ga-68-PSMA-PET/CT and a radical prostatectomy. CNAs were directly correlated to imaging features and radiogenomic analyses were performed. Highly significant CNAs (>= 10 M bp) were found in 22 of 46 biopsies. Chromosome 8p, 13q and 5q losses were the most common findings. There was an strong correspondence between the radiologic and the genomic index lesions. The radiogenomic analyses suggest the feasibility of developing radiologic signatures that can distinguish between genomically more or less aggressive lesions. In conclusion, imaging features of mpMRI and Ga-68-PSMA-PET/CT can guide to the genomically most aggressive lesion of a PCa. Radiogenomics may help to better differentiate between indolent and aggressive PCa in the future.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kesch, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radtke, Jan-PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wintsche, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesenfarth, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luttje, MariskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasch, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieffenbacher, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pecqueux, CarineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teber, DoguUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatiboglu, GencayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nyarangi-Dix, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simpfendoerfer, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenberg, GitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dimitrakopoulou-Strauss, AntoniaUNSPECIFIEDorcid.org/0000-0003-0338-9472UNSPECIFIED
Freitag, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duensing, AnetteUNSPECIFIEDorcid.org/0000-0002-0168-4067UNSPECIFIED
Gruellich, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goetz, MichaelUNSPECIFIEDorcid.org/0000-0003-0984-224XUNSPECIFIED
Grabe, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweiger, Michal-RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pahernik, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perner, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herpel, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, WilfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieczorek, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier-Hein, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debus, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haberkorn, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giesel, FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galle, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hadaschik, BorisUNSPECIFIEDorcid.org/0000-0002-1052-2692UNSPECIFIED
Schlemmer, Heinz-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hohenfellner, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonekamp, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sueltmann, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duensing, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-165793
DOI: 10.1038/s41598-018-35058-3
Journal or Publication Title: Sci Rep
Volume: 8
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COPY NUMBER ALTERATIONS; DIAGNOSTIC-ACCURACY; ULTRASOUND FUSION; BIOPSY; HETEROGENEITY; EXPRESSION; EXTENT; MRIMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16579

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