Universität zu Köln

Spec, Andrej ORCID: 0000-0001-7612-4710, Mejia-Chew, Carlos, Powderly, William G. and Cornely, Oliver A. (2018). EQUAL Cryptococcus Score 2018: A European Confederation of Medical Mycology Score Derived From Current Guidelines to Measure QUALity of Clinical Cryptococcosis Management. Open Forum Infect. Dis., 5 (11). CARY: OXFORD UNIV PRESS INC. ISSN 2328-8957

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Abstract

Cryptococcocis is an opportunistic fungal infection with high morbidity and mortality. Guidelines to aid clinicians regarding diagnosis, management, and treatment can be extensive and challenging to comply with. There is no tool to measure guideline adherence. To create such a tool, we reviewed current guidelines from the Infectious Diseases Society of America, the World Health Organization, the American Society of Transplantation, and recent significant publications to select the strongest recommendations as vital components of our scoring tool. Items included diagnostic tests (blood, tissue, and cerebrospinal fluid cultures, Cryptococcus antigen, India ink, histopathology with special fungal stains, central nervous system imaging), pharmacological (amphotericin B, flucytosine, azoles) and nonpharmacological treatments (intracranial pressure management, immunomodulation, infectious disease consultation), and follow-up of central nervous system complications. The EQUAL Cryptococcus Score 2018 weighs and aggregates the recommendations for the optimal management of cryptococcosis. Providing a tool that could measure guideline adherence or facilitate clinical decision-making.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Spec, Andrej UNSPECIFIED orcid.org/0000-0001-7612-4710 UNSPECIFIED Mejia-Chew, Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Powderly, William G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-166310
DOI:	10.1093/ofid/ofy299
Journal or Publication Title:	Open Forum Infect. Dis.
Volume:	5
Number:	11
Date:	2018
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	2328-8957
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLACEBO-CONTROLLED TRIAL; AMPHOTERICIN-B; CEREBROSPINAL-FLUID; MENINGITIS; FLUCONAZOLE; FLUCYTOSINE; DISEASE; DIAGNOSIS; PRESSURE; THERAPY Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16631