Universität zu Köln

Weber, Alexander N. R., Gloria, Yamel Cardona, Cinar, Oezcan, Reinhardt, H. Christian, Pezzutto, Antonio and Wolz, Olaf-Oliver (2018). Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities. Cancer Immunol. Immunother., 67 (11). S. 1797 - 1808. NEW YORK: SPRINGER. ISSN 1432-0851

Full text not available from this repository.

Abstract

Oncogenic MYD88 mutations, most notably the Leu 265 Pro (L265P) mutation, were recently identified as potential driver mutations in various B-cell non-Hodgkin Lymphomas (NHLs). The L265P mutation is now thought to be common to virtually all NHLs and occurs in between 4 and 90% of cases, depending on the entity. Since it is tumor-specific, the mutation, and the pathways it regulates, might serve as advantageous therapeutic targets for both conventional chemotherapeutic intervention, as well as immunotherapeutic strategies. Here, we review recent progress on elucidating the molecular and cellular processes affected by theL265P mutation of MYD88, describe a new in vivo model for MyD88 L265P-mediated oncogenesis, and summarize how these findings could be exploited therapeutically by specific targeting of signaling pathways. In addition, we summarize current and explore future possibilities for conceivable immunotherapeutic approaches, such as L265P-derived peptide vaccination, adoptive transfer of L265P-restricted T cells, and use of T-cell receptor-engineered T cells. With clinical trials regarding their efficacy rapidly expanding to NHLs, we also discuss potential combinations of immune checkpoint inhibitors with the described targeted chemotherapies of L265P signaling networks, and/or with the above immunological approaches as potential ways of targeting MYD88-mutated lymphomas in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weber, Alexander N. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gloria, Yamel Cardona UNSPECIFIED UNSPECIFIED UNSPECIFIED Cinar, Oezcan UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, H. Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Pezzutto, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolz, Olaf-Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-166716
DOI:	10.1007/s00262-018-2242-9
Journal or Publication Title:	Cancer Immunol. Immunother.
Volume:	67
Number:	11
Page Range:	S. 1797 - 1808
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0851
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELL LYMPHOMA; NF-KAPPA-B; CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKIN-LYMPHOMA; MHC CLASS-I; WALDENSTROM MACROGLOBULINEMIA; TIR-DOMAIN; CHECKPOINT BLOCKADE; TYROSINE KINASE; ACTIVATION Multiple languages Oncology; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16671