Universität zu Köln

Wu, Jiangping, Li, Xia, Zhao, Jianping, Wang, Ruijuan, Xia, Zifei, Li, Xiaoran, Liu, Yanli, Xu, Qiongming, Khan, Ikhlas A. and Yang, Shilin (2018). Anti-inflammatory and cytotoxic withanolides from Physalis minima. Phytochemistry, 155. S. 164 - 171. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0031-9422

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Abstract

Six undescribed withanolides were isolated and characterized during the investigation of anti-inflammatory and cytotoxic constituents from the whole plants of Physalis minima L. Their structures were elucidated by extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR), and their anti-inflammatory and cytotoxic activities were evaluated in vitro. All the compounds exhibited anti-inflammatory ability via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Moderate cytotoxic activities against A549 lung adenocarcinoma cells, SMMC-7721 hepatic carcinoma cells and MCF-7 breast cancer cells with IC50 values in the range of 40.01-82.17 mu M were observed for these withanolides.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wu, Jiangping UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xia UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Jianping UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Ruijuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Xia, Zifei UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xiaoran UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Yanli UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Qiongming UNSPECIFIED UNSPECIFIED UNSPECIFIED Khan, Ikhlas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Shilin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-167288
DOI:	10.1016/j.phytochem.2018.08.009
Journal or Publication Title:	Phytochemistry
Volume:	155
Page Range:	S. 164 - 171
Date:	2018
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0031-9422
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRYPANOCIDAL CONSTITUENTS; AERIAL PARTS; NITRIC-OXIDE; ANGULATA Multiple languages Biochemistry & Molecular Biology; Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16728