Universität zu Köln

Fish, Simon, Toumaian, Maida, Pappa, Eleni, Davies, Timothy J., Tanti, Ruth, Saville, Christopher W. N., Theleritis, Christos ORCID: 0000-0002-7313-6908, Economou, Marina ORCID: 0000-0002-6742-4348, Klein, Christoph and Smyrnis, Nikolaos (2018). Modelling reaction time distribution of fast decision tasks in schizophrenia: Evidence for novel candidate endophenotypes. Psychiatry Res., 269. S. 212 - 221. CLARE: ELSEVIER IRELAND LTD. ISSN 0165-1781

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Abstract

Increased reaction time (RT) and variability of RT in fast decision tasks is observed in patients with schizophrenia and their first degree relatives. This study used modelling of the RT distribution with the aim of identifying novel candidate endophenotypes for schizophrenia. 20 patients with schizophrenia, 15 siblings of patients and 25 healthy controls performed an oddball task of varying working memory load. Increases in mean and standard deviation (SD) of RT were observed for both patients and siblings compared to controls and they were again independent of working memory load. Ex-Gaussian modelling of the RT distribution confirmed that parameters mu, sigma and tau increased significantly in patients and siblings compared to controls. The Drift Diffusion Model was applied on RT distributions. A decrease in the diffusion drift rate (v) modeling the accumulation of evidence for reaching the decision to choose one stimulus over the other, was observed in patients and siblings compared to controls. The mean time of the non-decisional sensorimotor processes (t0) and it's variance (st0) was also increased in patients and siblings compared to controls. In conclusion modeling of the RT distribution revealed novel potential cognitive endophenotypes in the quest of heritable risk factors for schizophrenia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fish, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Toumaian, Maida UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappa, Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Davies, Timothy J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tanti, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Saville, Christopher W. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Theleritis, Christos UNSPECIFIED orcid.org/0000-0002-7313-6908 UNSPECIFIED Economou, Marina UNSPECIFIED orcid.org/0000-0002-6742-4348 UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-167328
DOI:	10.1016/j.psychres.2018.08.067
Journal or Publication Title:	Psychiatry Res.
Volume:	269
Page Range:	S. 212 - 221
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0165-1781
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORKING-MEMORY DEFICITS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DIFFUSION-MODEL; 1ST-DEGREE RELATIVES; EXECUTIVE FUNCTION; NEURODEVELOPMENTAL HYPOTHESIS; NAIVE SCHIZOPHRENIA; PERFORMANCE; VARIABILITY; ADHD Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16732