Universität zu Köln

Ripp, Caroline, Loth, Julia, Petrova, Iveta, Linnemannstoens, Karen, Ulepic, Monique, Fradkin, Lee, Noordermeer, Jasprien and Wodarz, Andreas ORCID: 0000-0002-0007-6289 (2018). Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands. Biol. Open, 7 (11). CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 2046-6390

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Abstract

Wnt ligands are secreted glycoproteins that control many developmental processes and are crucial for homeostasis of numerous tissues in the adult organism. Signal transduction of Wnts involves the binding of Wnts to receptor complexes at the surface of target cells. These receptor complexes are commonly formed between a member of the Frizzled family of seven-pass transmembrane proteins and a co-receptor, which is usually a single-pass transmembrane protein. Among these co-receptors are several with structural homology to receptor tyrosine kinases, including Ror, PTK7, Ryk and MUSK. In vertebrates, Ror-2 and PTK7 are important regulators of planar cell polarity (PCP). By contrast, PCP phenotypes were not reported for mutations in off-track (otk) and off-track2 (otk2), encoding the Drosophila orthologs of PTK7. Here we show that Drosophila Ror is expressed in the nervous system and localizes to the plasma membrane of perikarya and neurites. A null allele of Ror is homozygous viable and fertile, does not display PCP phenotypes and interacts genetically with mutations in otk and otk2. We show that Ror binds specifically to Wingless (Wg), Wnt4 and Wnt5 and also to Frizzled2 (Fz2) and Otk. Our findings establish Drosophila Ror as a Wnt co-receptor expressed in the nervous system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ripp, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Loth, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrova, Iveta UNSPECIFIED UNSPECIFIED UNSPECIFIED Linnemannstoens, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulepic, Monique UNSPECIFIED UNSPECIFIED UNSPECIFIED Fradkin, Lee UNSPECIFIED UNSPECIFIED UNSPECIFIED Noordermeer, Jasprien UNSPECIFIED UNSPECIFIED UNSPECIFIED Wodarz, Andreas UNSPECIFIED orcid.org/0000-0002-0007-6289 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-167540
DOI:	10.1242/bio.033001
Journal or Publication Title:	Biol. Open
Volume:	7
Number:	11
Date:	2018
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2046-6390
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR TYROSINE KINASE; PLANAR CELL POLARITY; PTK7; FAMILY; MORPHOGENESIS; MOVEMENTS; EXTENSION; WINGLESS; PATHWAY; PROTEIN Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16754