Universität zu Köln

Reuter, Hannes, Herkenrath, Simon, Treml, Marcel, Halbach, Marcel, Steven, Daniel, Frank, Konrad, Castrogiovanni, Alessandra, Kietzmann, Ilona, Baldus, Stephan and Randerath, Winfried J. (2018). Sleep-disordered breathing in patients with cardiovascular diseases cannot be detected by ESS, STOP-BANG, and Berlin questionnaires. Clin. Res. Cardiol., 107 (11). S. 1071 - 1079. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular diseases (CVD) and associated with poor outcome. At least 50% of heart failure (HF) patients present with SDB, equally divided in obstructive sleep apnea (OSA) and central sleep apnea (CSA). CVD patients with SDB do not always present with typical SDB symptoms. Therefore, we asked whether established questionnaires allow for the reliable detection of SDB. In this prospective cohort study, 89 CVD patients (54 male, 59 +/- 15 years, BMI 30 +/- 6kg/m(2)) in stable clinical state underwent an ambulatory polygraphy. SDB was defined as an apnea-hypopnea index (AHI)15/h. We evaluated the Epworth Sleepiness Scale (ESS), STOP-BANG and Berlin questionnaires as well as anthropometric data and comorbidities regarding their ability to predict SDB. The ESS showed no correlation with SDB. The sensitivity of the Berlin Questionnaire to detect SDB was 73%, specificity was 42%. The STOP-BANG questionnaire showed a sensitivity of 97% while specificity was 13%. Coronary heart disease and/or history of myocardial infarction, hyperuricemia and age significantly contributed to a logistic regression model predicting presence of SDB. However, our regression model explains only 36% of the variance regarding the presence or absence of SDB. The approach to find variables, which would allow an early and reliable differentiation between patients with CVD and coexistence or absence of SDB, failed. Thus, as CVD patients show a high SDB prevalence and poor outcome, only a systematic screening based on measures of respiration-related parameters (i.e., respiratory flow, blood oxygen saturation, etc.) allows for a reliable SDB assessment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reuter, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Herkenrath, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Halbach, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Konrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Castrogiovanni, Alessandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Kietzmann, Ilona UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168207
DOI:	10.1007/s00392-018-1282-7
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	107
Number:	11
Page Range:	S. 1071 - 1079
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADAPTIVE SERVO-VENTILATION; CHEYNE-STOKES RESPIRATION; POSITIVE AIRWAY PRESSURE; SYSTOLIC HEART-FAILURE; ATRIAL-FIBRILLATION; RISK-FACTORS; APNEA; PREVALENCE; ASSOCIATION; FATIGUE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16820