Universität zu Köln

Xanthouli, P., Hermann, W., Hunzelmann, N. and Kreuter, M. (2018). Systemic sclerosis associated interstitial lung disease. Pneumologe, 15 (6). S. 383 - 396. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1613-6055

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Abstract

The involvement of the lungs in systemic sclerosis (SSc) is one of the most frequent organ manifestations and is afrequent cause of death among these patients. The course of SSc can be either stable or show slow or rapid progressive deterioration. In particular, interstitial lung disease (ILD) is associated with a poor prognosis and a high mortality and disability. The SSc-ILD often develops during the early phases of the disease. The timely diagnosis of the disease is of vital importance for survival of these patients. The most important indications for the diagnosis of SSc-ILD are the clinical presentation of the patient usually with coughing and progressive dyspnea, deterioration of lung function, the autoantibody constellation in addition to radiological imaging with thorax computed tomography (CT). Despite advances in treatment of SSc in general, there are still only limited specific possibilities for treatment of SSc-ILD, mostly relying on immunosuppression and other pharmacological options as well as lung and stem cell transplantation in selected cases. In severe cases the treatment strategy should be individualized in centers of expertise based on the disease course and the individual needs of the patient.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xanthouli, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168233
DOI:	10.1007/s10405-018-0204-8
Journal or Publication Title:	Pneumologe
Volume:	15
Number:	6
Page Range:	S. 383 - 396
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1613-6055
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; PLACEBO-CONTROLLED TRIAL; SCLERODERMA LUNG; MYCOPHENOLATE-MOFETIL; DOUBLE-BLIND; OPEN-LABEL; CYCLOPHOSPHAMIDE; SAFETY; CLASSIFICATION; TOCILIZUMAB Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16823