Universität zu Köln

Lohmann, Philipp ORCID: 0000-0002-5360-046X, Piroth, Marc D., Sellhaus, Bernd, Weis, Joachim, Geisler, Stefanie, Oros-Peusquens, Ana-Maria, Mohlberg, Hartmut, Amunts, Katrin, Shah, Nadim J., Galldiks, Norbert ORCID: 0000-0002-2485-1796 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2018). Correlation of Dynamic O-(2-[F-18]Fluoroethyl)-L-Tyrosine Positron Emission Tomography, Conventional Magnetic Resonance Imaging, and Whole-Brain Histopathology in a Pretreated Glioblastoma: A Postmortem Study. World Neurosurg., 119. S. E653 - 8. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

Full text not available from this repository.

Abstract

OBJECTIVE: Amino acid positron emission tomography (PET) using O-(2[F-1(8)]fluoroethyl)-L-tyrosine (FET) provides important additional information on the extent of viable tumor tissue of glioblastoma compared with magnetic resonance imaging (MRI). Especially after radio-chemotherapy, progression of contrast enhancement in MRI is equivocal and may represent either tumor progression or treatment-related changes. Here, the first case comparing postmortem whole-brain histology of a patient with pretreated glioblastoma with dynamic in vivo FET PET and MRI is presented. METHODS: A 61-year-old patient with glioblastoma initially underwent partial tumor resection and died 11 weeks after completion of chemoradiation with concurrent temozolomide. Three days before the patient died, a followup FET PET and MRI scan indicated tumor progression. Autopsy was performed 48 hours after death. After formalin fixation, a 7-cm bihemispherical segment of the brain containing the entire tumor mass was cut into 3500 consecutive 20 mu m coronal sections. Representative sections were stained with hematoxylin and eosin stain, cresyl violet, and glial fibrillary acidic protein immunohistochemistry. An experienced neuropathologist identified areas of dense and diffuse neoplastic infiltration, astrogliosis, and necrosis. In vivo FET PET, MRI datasets, and postmortem histology were co-registered and compared by 3 experienced physicians. RESULTS: Increased uptake of FET in the area of equivocal contrast enhancement on MRI correlated very well with dense infiltration by vital tumor cells and showed tracer kinetics typical for malignant gliomas. An area of predominantly reactive astrogliosis showed only moderate uptake of FET and tracer kinetics usually observed in benign lesions. CONCLUSIONS: This case report impressively documents the correct imaging of a progressive glioblastoma by FET PET.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Piroth, Marc D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sellhaus, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Weis, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Geisler, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Oros-Peusquens, Ana-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohlberg, Hartmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Amunts, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168282
DOI:	10.1016/j.wneu.2018.07.232
Journal or Publication Title:	World Neurosurg.
Volume:	119
Page Range:	S. E653 - 8
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMINO-ACID PET; LOW-GRADE GLIOMA; F-18-FET PET; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; EUROPEAN ASSOCIATION; COMPUTED-TOMOGRAPHY; RESPONSE ASSESSMENT; NEUROONCOLOGY; DIAGNOSIS; TUMORS Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16828