Universität zu Köln

Schmidt, Claudia C., Timpert, David C., Arend, Isabel, Vossel, Simone ORCID: 0000-0002-6351-8849, Dovern, Anna, Saliger, Jochen, Karbe, Hans, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Henik, Avishai ORCID: 0000-0002-5665-6004 and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2018). Preserved but Less Efficient Control of Response Interference After Unilateral Lesions of the Striatum. Front. Hum. Neurosci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5161

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Abstract

Previous research on the neural basis of cognitive control processes has mainly focused on cortical areas, while the role of subcortical structures in cognitive control is less clear. Models of basal ganglia function as well as clinical studies in neurodegenerative diseases suggest that the striatum (putamen and caudate nucleus) modulates the inhibition of interfering responses and thereby contributes to an important aspect of cognitive control, namely response interference control. To further investigate the putative role of the striatum in the control of response interference, 23 patients with stroke-induced lesions of the striatum and 32 age-matched neurologically healthy controls performed a unimanual version of the Simon task. In the Simon task, the correspondence between stimulus location and response location is manipulated so that control over response interference can be inferred from the reaction time costs in incongruent trials. Results showed that stroke patients responded overall slower and more erroneous than controls. The difference in response times (RTs) between incongruent and congruent trials (known as the Simon effect) was smaller in the ipsilesional/-lateral hemifield, but did not differ significantly between groups. However, in contrast to controls, stroke patients exhibited an abnormally stable Simon effect across the reaction time distribution indicating a reduced efficiency of the inhibition process. Thus, in stroke patients unilateral lesions of the striatum did not significantly impair the general ability to control response interference, but led to less efficient selective inhibition of interfering responses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Claudia C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timpert, David C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arend, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Vossel, Simone UNSPECIFIED orcid.org/0000-0002-6351-8849 UNSPECIFIED Dovern, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Saliger, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbe, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Henik, Avishai UNSPECIFIED orcid.org/0000-0002-5665-6004 UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-169221
DOI:	10.3389/fnhum.2018.00414
Journal or Publication Title:	Front. Hum. Neurosci.
Volume:	12
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR CINGULATE CORTEX; BASAL GANGLIA LESIONS; PARKINSONS-DISEASE; COGNITIVE CONTROL; INDIVIDUAL-DIFFERENCES; HUNTINGTONS-DISEASE; SIMON TASK; PREFRONTAL CORTEX; COMPUTATIONAL MODEL; EXECUTIVE FUNCTIONS Multiple languages Neurosciences; Psychology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16922