Universität zu Köln

Teller, Inga C., Hoyer-Kuhn, Heike, Broenneke, Hella, Nosthoff-Horstmann, Pia, Oosting, Annemarie, Lippach, Gregor, Wohlfarth, Maria, Rauh, Manfred, van der Beek, Eline M., Doetsch, Joerg and Nuesken, Kai D. (2018). Complex lipid globules in early-life nutrition improve long-term metabolic phenotype in intra-uterine growth-restricted rats. Br. J. Nutr., 120 (7). S. 763 - 777. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1475-2662

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Abstract

hum-uterine growth restriction (IUGR) is associated with adverse metabolic outcome later in life. Healthy mice challenged with a Western-style diet (WSD) accumulated less body fat when previously fed a diet containing large lipid globules (complex lipid matrix (CLM)). This study was designed to clarify whether an early-life CLM diet mitigates 'programmed' visceral adiposity and associated metabolic sequelae after IUGR. In rats, IUGR was induced either by bilateral uterine vessel ligation (LIG) or sham operation (i.e. intra-uterine stress) of the dam on gestational day 19. Offspring from non-operated (NOP) darns served as controls. Male offspring of all groups were either fed CLM or `normal matrix' control diet (CTRL) from postnatal clays (PND) 15 to 42. Thereafter, animals were challenged with a mild WSD until dissection (PND 98). Fat mass (micro computer-tomograph scan: weight of fat compartments), circulating metabolic markers and expression of 'metabolic' genes (quantitative real-time PCR) were assessed. CLM diet significantly reduced visceral fat mass in LIG at PND 40. At dissection, visceral fat mass, fasted blood glucose, TAG and leptin concentrations were significantly increased in LIG-CTRL v. NOP-CTRL, and significantly decreased in LIG-CLM v. LIG-CTRL. Gene expression levels of leptin (mesenteric fat) and insulin-like growth factor 1 (liver) were significantly reduced in LIG-CLM v. LIG-CTRL. In conclusion, early-life CLM diet mitigated the adverse metabolic phenotype after utero-placental insufficiency. The supramolecular structure of dietary lipids may be a novel aspect of nutrient quality that has to be considered in the context of primary prevention of obesity and metabolic disease in at-risk populations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Teller, Inga C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer-Kuhn, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Broenneke, Hella UNSPECIFIED UNSPECIFIED UNSPECIFIED Nosthoff-Horstmann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Oosting, Annemarie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippach, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlfarth, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauh, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Beek, Eline M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Kai D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-169369
DOI:	10.1017/S0007114518001988
Journal or Publication Title:	Br. J. Nutr.
Volume:	120
Number:	7
Page Range:	S. 763 - 777
Date:	2018
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1475-2662
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILK-FAT GLOBULE; FOR-GESTATIONAL-AGE; EARLY POSTNATAL LIFE; CATCH-UP GROWTH; UTEROPLACENTAL INSUFFICIENCY; PROSPECTIVE COHORT; CHILDHOOD OBESITY; PRENATAL EXPOSURE; BODY-COMPOSITION; BLOOD-PRESSURE Multiple languages Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16936