Universität zu Köln

Schroeder, Julian and Moesges, Ralph (2018). Conjunctival provocation tests: prediction of seasonal allergy. Curr. Opin. Allergy Clin. Immunol., 18 (5). S. 393 - 398. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-6322

Full text not available from this repository.

Abstract

Purpose of review The conjunctival provocation test (CPT) is often used to clearly identify the specific allergen causing the symptoms of allergic rhinoconjunctivitis but also to assess the clinical efficacy of an allergen immunotherapy (AIT). As there is no consensus about its predictive value, the aim of this publication is to evaluate under which conditions the CPT can predict the symptom severity during the allergy season after previous AIT. Recent findings Three out of four randomized controlled trials (RCTs) showed a correlation between CPT reactivity and symptoms occurring under natural allergen exposure after previous AIT. Furthermore, one RCT found that performing the CPT 4 weeks after initiating AIT can identify early responders who also show a benefit during the season. Another RCT suggested that conducting the CPT prior to starting AIT can be used to identify patients who may benefit more from treatment than others. Summary The assessment of the reviewed literature led us to the conclusion that the CPT has a predictive value and can consequently be used to assess the efficacy of an administered AIT if performed according to a standardized challenge protocol with high-quality allergen extracts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schroeder, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-169899
DOI:	10.1097/ACI.0000000000000470
Journal or Publication Title:	Curr. Opin. Allergy Clin. Immunol.
Volume:	18
Number:	5
Page Range:	S. 393 - 398
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-6322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RHINOCONJUNCTIVITIS; SEVERITY Multiple languages Allergy; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16989