Universität zu Köln

Thangarajah, Fabinshy, Vogel, Constanze, Pahmeyer, Caroline, Eichler, Christian, Holtschmidt, Johannes, Ratiu, Dominik, Mallmann, Peter and Malter, Wolfram (2018). Profile and Outcome of Supraclavicular Metastases in Patients with Metastatic Breast Cancer: Discordance of Receptor Status Between Primary and Metastatic Site. Anticancer Res., 38 (10). S. 6023 - 6027. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background: Breast cancer is a heterogenous and complex disease. A rare site of metastatic breast cancer disease is the neck. Data about supraclavicular metastases in patients with metastatic breast cancer are still lacking. Hence, our study aimed to analyze histological subtypes of supraclavicular metastases compared to the primary site. Materials and Methods: This was a retrospective hospital-based cohort study of patients with breast cancer who developed supraclavicular metastases. Diagnosis of supraclavicular metastases was confirmed by biopsy or diagnostic lymph node extirpation. Histological subtypes were analyzed and Kaplan-Meier estimates were calculated for overall survival. Results: A total of 20 patients were included in the analysis. The majority of the patients (12/20) had hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative supraclavicular metastases, disease in 3/20 patients was HR-positive/HER2-positive, HRnegative/HER2-positive in 1/20 patients and basal-like in 4/20 patients. Total discordance rates for estrogen receptor, progesterone receptor and HER2 between primary and metastatic tumors were 20.0%, 36.8% and 29.4%, respectively. The 5-year overall survival was 80%, whereas the 5-year survival after the onset of neck metastasis was 45%. Conclusion: As a rare site of metastatic breast cancer, supraclavicular metastases are associated with a worse median overall survival from their onset. The high rate of discordance of histological subtype stresses the necessity for biopsies in patients with supraclavicular metastasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thangarajah, Fabinshy UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogel, Constanze UNSPECIFIED UNSPECIFIED UNSPECIFIED Pahmeyer, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtschmidt, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Ratiu, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170074
DOI:	10.21873/anticanres.12952
Journal or Publication Title:	Anticancer Res.
Volume:	38
Number:	10
Page Range:	S. 6023 - 6027
Date:	2018
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESTROGEN-RECEPTOR; PROGNOSTIC IMPACT; HORMONE; METAANALYSIS; CONVERSION; SUBTYPES; 1ST Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17007