Universität zu Köln

Kube, Jana, Mathar, David ORCID: 0000-0003-3411-7867, Horstmann, Annette ORCID: 0000-0001-6184-8484, Kotz, Sonja A., Villringer, Arno and Neumann, Jane (2018). Altered monetary loss processing and reinforcement-based learning in individuals with obesity. Brain Imaging Behav., 12 (5). S. 1431 - 1450. NEW YORK: SPRINGER. ISSN 1931-7565

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Abstract

Individuals with obesity are often characterized by alterations in reward processing. This may affect how new information is used to update stimulus values during reinforcement-based learning. Here, we investigated obesity-related changes in non-food reinforcement processing, their impact on learning performance as well as the neural underpinnings of reinforcement-based learning in obesity. Nineteen individuals with obesity (BMI>=30kg/m(2), 10 female) and 23 lean control participants (BMI 18.5-24.9kg/m(2), 11 female) performed a probabilistic learning task during functional magnetic resonance imaging (fMRI), in which they learned to choose between advantageous and disadvantageous choice options in separate monetary gain, loss, and neutral conditions. During learning individuals with obesity made a significantly lower number of correct choices and accumulated a significantly lower overall monetary outcome than lean control participants. FMRI analyses revealed aberrant medial prefrontal cortex responses to monetary losses in individuals with obesity. There were no significant group differences in the regional representation of prediction errors. However, we found evidence for increased functional connectivity between the ventral striatum and insula in individuals with obesity. The present results suggest that obesity is associated with aberrant value representations for monetary losses, alterations in functional connectivity during the processing of learning outcomes, as well as a decresased reinforcement-based learning performance. This may affect how new information is incorporated to adjust dysfunctional behavior and could be a factor contributing to the maintenance of dysfunctional eating behavior in obesity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kube, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathar, David UNSPECIFIED orcid.org/0000-0003-3411-7867 UNSPECIFIED Horstmann, Annette UNSPECIFIED orcid.org/0000-0001-6184-8484 UNSPECIFIED Kotz, Sonja A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Villringer, Arno UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170119
DOI:	10.1007/s11682-017-9786-8
Journal or Publication Title:	Brain Imaging Behav.
Volume:	12
Number:	5
Page Range:	S. 1431 - 1450
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1931-7565
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; REWARD PREDICTION ERRORS; WORKING-MEMORY; CONFIDENCE-INTERVALS; NUCLEUS-ACCUMBENS; STRIATAL RESPONSE; SEEKING BEHAVIOR; DECISION-MAKING; ANTERIOR INSULA; NEURAL BASIS Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17011