Universität zu Köln

Akhtar-Schaefer, Isha, Wang, Luping, Krohne, Tim U., Xu, Heping ORCID: 0000-0003-4000-931X and Langmann, Thomas (2018). Modulation of three key innate immune pathways for the most common retinal degenerative diseases. EMBO Mol. Med., 10 (10). HOBOKEN: WILEY. ISSN 1757-4684

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Abstract

This review highlights the role of three key immune pathways in the pathophysiology of major retinal degenerative diseases including diabetic retinopathy, age-related macular degeneration, and rare retinal dystrophies. We first discuss the mechanisms how loss of retinal homeostasis evokes an unbalanced retinal immune reaction involving responses of local microglia and recruited macrophages, activity of the alternative complement system, and inflammasome assembly in the retinal pigment epithelium. Presenting these key mechanisms as complementary targets, we specifically emphasize the concept of immunomodulation as potential treatment strategy to prevent or delay vision loss. Promising molecules are ligands for phagocyte receptors, specific inhibitors of complement activation products, and inflammasome inhibitors. We comprehensively summarize the scientific evidence for this strategy from preclinical animal models, human ocular tissue analyses, and clinical trials evolving in the last few years.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Akhtar-Schaefer, Isha UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Luping UNSPECIFIED UNSPECIFIED UNSPECIFIED Krohne, Tim U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Heping UNSPECIFIED orcid.org/0000-0003-4000-931X UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170179
DOI:	10.15252/emmm.201708259
Journal or Publication Title:	EMBO Mol. Med.
Volume:	10
Number:	10
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1757-4684
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NLRP3 INFLAMMASOME ACTIVATION; PIGMENT EPITHELIAL-CELLS; OPTICAL COHERENCE TOMOGRAPHY; MEMBRANE ATTACK COMPLEX; ADENOSINE A(2A) RECEPTORS; NF-KAPPA-B; INDUCED CHOROIDAL NEOVASCULARIZATION; PROLIFERATIVE DIABETIC-RETINOPATHY; PATTERN-RECOGNITION RECEPTORS; NECROSIS-FACTOR-ALPHA Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17017