Universität zu Köln

Wetzel, Christian, Goertz, Lukas, Schulte, Andre Pascal, Goldbrunner, Roland and Krischek, Boris (2018). Minimizing overdrainage with flow-regulated valves - Initial results of a prospective study on idiopathic normal pressure hydrocephalus. Clin. Neurol. Neurosurg., 173. S. 31 - 38. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-6968

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Abstract

Objective: Overdrainage and frequent reprogramming are common issues with programmable valves after ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH). Flow-regulated valves may address these limitations, but data on their efficacy are sparse. We present our single-center experience with flow-regulated valves focusing on overdrainage and efficiency. Patients and methods: Thirty-two patients with iNPH treated with the Integra (R) NPH Low Flow Valve were prospectively enrolled. Clinical evaluation was performed at baseline, postoperatively as well as 3 and 6 months after surgery. The outcome was assessed by employing the iNPH grading scale and the Mini Mental Status Examination (MMSE). Overdrainage was assessed clinically and radiologically by computed tomography. Results: The mean patient age was 71 years. All patients presented with gait disturbance, 29 had cognitive impairment and 25 had urinary incontinence. The mean duration of symptoms was 22.9 months. At 3 month follow up, 25/31 patients (80.6%) improved on the total iNPH score by at least 5 points (p < 0.001). The mean MMSE score increased from 24.5 to 26.1 points (p = 0.013). After 6 months, the improvement rates of the iNPH (82.1%) and the MMSE scores (26.8 points) were stable. The rate of clinically significant overdrainage was 3.2%. One patient presented with subdural hygromas that necessitated evacuation. In the remaining patients, clinical and radiological signs of overdrainage were absent. Conclusion: The use of the Integra (R) NPH Low Flow Valve leads to a good neurological outcome and has low overdrainage rates without the need for reprogramming. These results are encouraging and justify further investigation of this valve.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wetzel, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Andre Pascal UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-171462
DOI:	10.1016/j.clineuro.2018.07.017
Journal or Publication Title:	Clin. Neurol. Neurosurg.
Volume:	173
Page Range:	S. 31 - 38
Date:	2018
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-6968
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADULT HYDROCEPHALUS; SURGICAL-TREATMENT; SHUNT VALVES; MULTICENTER; FREQUENCY; OUTCOMES; DEVICES; INPH Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17146