Universität zu Köln

Reimer, Robert P., Reimer, Peter and Mahnken, Andreas H. (2018). Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis. Cardiovasc. Interv. Radiol., 41 (10). S. 1545 - 1557. NEW YORK: SPRINGER. ISSN 1432-086X

Full text not available from this repository.

Abstract

To determine whether post-treatment magnetic resonance imaging (MRI)-based texture analysis of liver metastases (LM) may be suited predicting therapy response to transarterial radioembolization (TARE) during follow-up. Thirty-seven patients with LM treated by TARE (mean age 63.4 years) between January 2006 and December 2014 were identified in this retrospective feasibility study. They underwent dynamic contrast-enhanced and hepatocellular phase MRI after TARE (mean 2.2 days). Response was evaluated on follow-up imaging scheduled in intervals of 3 months (median follow-up, 7.3 months) based on response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Results of texture analysis [mean, standard deviation, skewness (s), kurtosis (k), entropy and uniformity] were compared between patients with progressive disease (PD) and patients with stable disease (SD), partial or complete response (PR/CR). Receiver operating characteristics including the area under the curve (AUC) and cutoff values including the sensitivity and specificity were calculated. According to RECIST 1.1, 24 patients (64.9%) had PD, 8 SD (21.6%) and 5 PR (13.5%). MRI-based texture analysis showed an earlier differentiation between patients with and without PD when compared with RECIST 1.1. Median k (2.88 vs. 2.35) in arterial phase MRI and median s (0.48 vs. 0.25) and k (2.85 vs. 2.25) in venous phase MRI were significantly different (p < 0.05). The AUC for k derived from arterial phase MRI was 0.73 (cutoff = 2.55, sensitivity = 0.83, specificity = 0.62) (p < 0.05). The AUC for s and k in venous phase MRI was 0.76 (cutoff = 0.35, sensitivity = 0.71, specificity = 0.85) (p > 0.05) and 0.83 (cutoff = 2.50, sensitivity = 0.75, specificity = 0.85) (p < 0.05). This study indicates the potential of MRI-based texture analysis at arterial and venous phase MRI for the early prediction of PD after TARE. IV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reimer, Robert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reimer, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahnken, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-172161
DOI:	10.1007/s00270-018-2004-2
Journal or Publication Title:	Cardiovasc. Interv. Radiol.
Volume:	41
Number:	10
Page Range:	S. 1545 - 1557
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-086X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATOCELLULAR-CARCINOMA; TUMOR HETEROGENEITY; Y-90 RADIOEMBOLIZATION; COLORECTAL-CANCER; HISTOGRAM ANALYSIS; IMAGING BIOMARKER; PREDICTING RESPONSE; MAGNETIC-RESONANCE; CT PERFUSION; SURVIVAL Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17216