Mendoza, Pilar, Gruell, Henning, Nogueira, Lilian, Pai, Joy A., Butler, Allison L., Millard, Katrina, Lehmann, Clara, Suarez, Isabelle, Oliveira, Thiago Y., Lorenzi, Julio C. C., Cohen, Yehuda Z., Wyen, Christoph, Kuemmerle, Tim, Karagounis, Theodora ORCID: 0000-0003-1481-9589, Lu, Ching-Lan, Handl, Lisa, Unson-O'Brien, Cecilia, Patel, Roshni, Ruping, Carola, Schlotz, Maike, Witmer-Pack, Maggi, Shimeliovich, Irina, Kremer, Gisela, Thomas, Eleonore, Seaton, Kelly E., Horowitz, Jill, West, Anthony P., Jr., Bjorkman, Pamela J., Tomaras, Georgia D., Gulick, Roy M., Pfeifer, Nico, Faetkenheuer, Gerd, Seaman, Michael S., Klein, Florian, Caskey, Marina and Nussenzweig, Michel C. (2018). Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature, 561 (7724). S. 479 - 497. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

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Abstract

Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal anti-HIV-1 broadly neutralizing antibodies that target independent sites on the HIV-1 envelope spike, was administered during analytical treatment interruption. Participants received three infusions of 30 mg kg(-1) of each antibody at 0, 3 and 6 weeks. Infusions of the two antibodies were generally well-tolerated. The nine enrolled individuals with antibody-sensitive latent viral reservoirs maintained suppression for between 15 and more than 30 weeks (median of 21 weeks), and none developed viruses that were resistant to both antibodies. We conclude that the combination of the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 can maintain long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mendoza, PilarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruell, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogueira, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pai, Joy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butler, Allison L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Millard, KatrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suarez, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliveira, Thiago Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenzi, Julio C. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen, Yehuda Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuemmerle, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karagounis, TheodoraUNSPECIFIEDorcid.org/0000-0003-1481-9589UNSPECIFIED
Lu, Ching-LanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handl, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unson-O'Brien, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, RoshniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruping, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlotz, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witmer-Pack, MaggiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shimeliovich, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kremer, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, EleonoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seaton, Kelly E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horowitz, JillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
West, Anthony P., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjorkman, Pamela J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomaras, Georgia D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gulick, Roy M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, NicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seaman, Michael S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caskey, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nussenzweig, Michel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-172421
DOI: 10.1038/s41586-018-0531-2
Journal or Publication Title: Nature
Volume: 561
Number: 7724
Page Range: S. 479 - 497
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-4687
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BROADLY NEUTRALIZING ANTIBODIES; PRIMARY HIV-INFECTION; TREATMENT INTERRUPTION; HUMANIZED MICE; PASSIVE TRANSFER; DURABLE CONTROL; SHIV INFECTION; T-CELLS; IN-VIVO; RESERVOIRMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17242

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