Universität zu Köln

Mayseless, Oded ORCID: 0000-0002-9556-8541, Berns, Dominic S., Yu, Xiaomeng M., Riemensperger, Thomas, Fiala, Andre ORCID: 0000-0002-9745-5145 and Schuldiner, Oren ORCID: 0000-0002-7350-9380 (2018). Developmental Coordination during Olfactory Circuit Remodeling in Drosophila. Neuron, 99 (6). S. 1204 - 1221. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

Developmental neuronal remodeling is crucial for proper wiring of the adult nervous system. While remodeling of individual neuronal populations has been studied, how neuronal circuits remodel-and whether remodeling of synaptic partners is coordinated-is unknown. We found that the Drosophila anterior paired lateral (APL) neuron undergoes stereotypic remodeling during metamorphosis in a similar time frame as the mushroom body (MB) gamma-neurons, with whom it forms a functional circuit. By simultaneously manipulating both neuronal populations, we found that cell-autonomous inhibition of gamma-neuron pruning resulted in the inhibition of APL pruning in a process that is mediated, at least in part, by Ca2+-Calmodulin and neuronal activity dependent interaction. Finally, ectopic unpruned MB gamma axons display ectopic connections with the APL, as well as with other neurons, at the adult, suggesting that inhibiting remodeling of one neuronal type can affect the functional wiring of the entire micro-circuit.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mayseless, Oded UNSPECIFIED orcid.org/0000-0002-9556-8541 UNSPECIFIED Berns, Dominic S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Xiaomeng M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemensperger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiala, Andre UNSPECIFIED orcid.org/0000-0002-9745-5145 UNSPECIFIED Schuldiner, Oren UNSPECIFIED orcid.org/0000-0002-7350-9380 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-172635
DOI:	10.1016/j.neuron.2018.07.050
Journal or Publication Title:	Neuron
Volume:	99
Number:	6
Page Range:	S. 1204 - 1221
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B ECDYSONE RECEPTOR; MUSHROOM BODY; SYNAPTIC-TRANSMISSION; UBIQUITIN-PROTEASOME; TARGETED EXPRESSION; MOSAIC ANALYSIS; NEURONS; MEMORY; DEGENERATION; REQUIREMENT Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17263