Universität zu Köln

Tamirisa, Srividya, Papagiannouli, Fani ORCID: 0000-0003-4094-6688, Rempel, Eugen, Ermakova, Olga, Trost, Nils ORCID: 0000-0002-5171-018X, Zhou, Jun ORCID: 0000-0002-2101-9304, Mundorf, Juliane, Brunel, Samantha, Ruhland, Naima, Boutros, Michael ORCID: 0000-0002-9458-817X, Lohmann, Jan U. and Lohmann, Ingrid (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Reports, 24 (11). S. 3072 - 3087. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

The niche critically controls stem cell behavior, but its regulatory input at the whole-genome level is poorly understood. We elucidated transcriptional programs of the somatic and germline lineages in the Drosophila testis and genome-wide binding profiles of Zfh-1 and Abd-A expressed in somatic support cells and crucial for fate acquisition of both cell lineages. We identified key roles of nucleoporins and V-ATPase proton pumps and demonstrate their importance in controlling germline development from the support side. To make our dataset publicly available, we generated an interactive analysis tool, which uncovered conserved core genes of adult stem cells across species boundaries. We tested the functional relevance of these genes in the Drosophila testis and intestine and found a high frequency of stem cell defects. In summary, our dataset and interactive platform represent versatile tools for identifying gene networks active in diverse stem cell types.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tamirisa, Srividya UNSPECIFIED UNSPECIFIED UNSPECIFIED Papagiannouli, Fani UNSPECIFIED orcid.org/0000-0003-4094-6688 UNSPECIFIED Rempel, Eugen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ermakova, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Trost, Nils UNSPECIFIED orcid.org/0000-0002-5171-018X UNSPECIFIED Zhou, Jun UNSPECIFIED orcid.org/0000-0002-2101-9304 UNSPECIFIED Mundorf, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunel, Samantha UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhland, Naima UNSPECIFIED UNSPECIFIED UNSPECIFIED Boutros, Michael UNSPECIFIED orcid.org/0000-0002-9458-817X UNSPECIFIED Lohmann, Jan U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173015
DOI:	10.1016/j.celrep.2018.08.013
Journal or Publication Title:	Cell Reports
Volume:	24
Number:	11
Page Range:	S. 3072 - 3087
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELF-RENEWAL; SOMATIC STEM; GENE-EXPRESSION; NUCLEAR-PORES; H+-ATPASE; TESTIS; NICHE; GERMLINE; PROLIFERATION; SPERMATOGENESIS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17301