Universität zu Köln

Sabour, Davood, Machado, Rui S. R., Pinto, Jose P., Rohani, Susan, Sahito, Raja G. A., Hescheler, Jurgen, Futschik, Matthias E. and Sachinidis, Agapios (2018). Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart. Mol. Ther.-Nucl. Acids, 12. S. 158 - 174. CAMBRIDGE: CELL PRESS. ISSN 2162-2531

Full text not available from this repository.

Abstract

Heart development is a complex process, tightly regulated by numerous molecular mechanisms. Key components of the regulatory network underlying heart development are transcription factors (TFs) and microRNAs (miRNAs), yet limited investigation of the role of miRNAs in heart development has taken place. Here, we report the first parallel genome-wide profiling of polyadenylated RNAs and miRNAs in a developing murine heart. These data enable us to identify dynamic activation or repression of numerous biological processes and signaling pathways. More than 200 miRNAs and 25 long non-coding RNAs were differentially expressed during embryonic heart development compared to the mature heart; most of these had not been previously associated with cardiogenesis. Integrative analysis of expression data and potential regulatory interactions suggested 28 miRNAs as novel regulators of embryonic heart development, representing a considerable expansion of the current repertoire of known cardiac miRNAs. To facilitate follow-up investigations, we constructed HeartMiR (http://heartmir.sysbiolab.eu), an open access database and interactive visualization tool for the study of gene regulation by miRNAs during heart development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sabour, Davood UNSPECIFIED UNSPECIFIED UNSPECIFIED Machado, Rui S. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinto, Jose P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohani, Susan UNSPECIFIED UNSPECIFIED UNSPECIFIED Sahito, Raja G. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Futschik, Matthias E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachinidis, Agapios UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173099
DOI:	10.1016/j.omtn.2018.04.018
Journal or Publication Title:	Mol. Ther.-Nucl. Acids
Volume:	12
Page Range:	S. 158 - 174
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2162-2531
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CIRCULATING MICRORNAS; IN-VIVO; CARDIOVASCULAR-DISEASES; CARDIAC FIBROBLASTS; GENE; TARGETS; DIFFERENTIATION; CARDIOGENESIS; CELLS; ROLES Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17309