Universität zu Köln

Mathar, David ORCID: 0000-0003-3411-7867, Wiehler, Antonius, Chakroun, Karima, Goltz, Dominique and Peters, Jan ORCID: 0000-0002-0195-5357 (2018). A potential link between gambling addiction severity and central dopamine levels: Evidence from spontaneous eye blink rates. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Accumulating evidence points at similarities between substance use disorders (SUD) and gambling disorder on the behavioral and neural level. In SUD, attenuation of striatal D2/3-receptor availability is a consistent finding, at least for stimulating substances. For gambling disorder, no clear association with striatal D2/3-receptor availability has been unveiled so far. With its presumably negligible dopaminergic toxicity, possible differences in receptor availability in gambling disorder might constitute a vulnerability marker. Spontaneous eye blink rate (sEBR) is discussed as a potential proxy measure for striatal dopamine D2/3-receptor availability. Here we examined sEBR in 21 male problem gamblers and 20 healthy control participants. In addition, participants completed a screening questionnaire for overall psychopathology and self-reported measures of alcohol and nicotine consumption. We found no significant difference in sEBR between gamblers and controls. However, in gamblers, sEBR was negatively associated with gambling severity and positively associated with psychopathology. A final exploratory analysis revealed that healthy controls with low sEBR displayed higher alcohol and nicotine consumption than healthy participants with high sEBR. Although the exact association between dopamine transmission and sEBR is still debated, our findings reveal that sEBR is sensitive to inter-individual differences in gambling disorder severity in problem gamblers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mathar, David UNSPECIFIED orcid.org/0000-0003-3411-7867 UNSPECIFIED Wiehler, Antonius UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakroun, Karima UNSPECIFIED UNSPECIFIED UNSPECIFIED Goltz, Dominique UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Jan UNSPECIFIED orcid.org/0000-0002-0195-5357 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173126
DOI:	10.1038/s41598-018-31531-1
Journal or Publication Title:	Sci Rep
Volume:	8
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; IMPULSE CONTROL DISORDERS; RECEPTOR AVAILABILITY; PATHOLOGICAL GAMBLERS; PARKINSONS-DISEASE; NUCLEUS-ACCUMBENS; VENTRAL STRIATUM; ALCOHOL DEPENDENCE; COCAINE ABUSERS; RELEASE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17312