Happel, Patrick ORCID: 0000-0001-5363-1568, Waag, Thilo, Schimke, Magdalena, Schweeberg, Sarah, Muzha, Andreas, Fortak, Katrin, Heesch, Daniel, Klask, Laura, Pilscheur, Mathias, Hoppe, Franziska, Lenders, Thomas, Meijer, Jan, Lepperdinger, Guenter and Krueger, Anke (2018). Intrinsically P-32-Labeled Diamond Nanoparticles for In Vivo Imaging and Quantification of Their Biodistribution in Chicken Embryos. Adv. Funct. Mater., 28 (36). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1616-3028

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Abstract

Nanoparticles, especially from carbon, have great potential in biomedicine. However, prior to clinical use, biocompatibility and biodistribution of these nanoobjects have to be assessed. Currently, particle detection is mostly based on surface-bound labels, inevitably altering materials' properties by surface modification. Further obstacles include bleaching, dissociation of labels from the surface, weak emission of fluorophores due to insufficient tissue opacity or hampered light penetration or the need for specific excitation wavelengths. These characteristics greatly constrain employment of such nanoparticles to address complex analytical questions. To overcome these drawbacks, the use of intrinsic structural features of nanoobjects is highly desirable: the particle surface remains unchanged and the nanoobject exhibits its innate behavior. Thus, for sensitive detection and quantification, labels should be incorporated in the nanoparticle core, thereby avoiding cleavage and warranting unchanged surface characteristics. The incorporation of clinically approved radionuclide P-32 into the lattice of nanodiamond particles using highly defined ion implantation is described here. The properties, uptake, and biodistribution are studied in vivo, in the developing hen's egg model (hen's egg test on chorioallantoic membrane assay). It is found that P-32 labeling of diamond nanoparticles allows their reliable localization and sensitive quantification in a cost efficient, highly reliable, and safe way using available autoradiographic devices and analytical methods.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Happel, PatrickUNSPECIFIEDorcid.org/0000-0001-5363-1568UNSPECIFIED
Waag, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schimke, MagdalenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweeberg, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muzha, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fortak, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesch, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klask, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilscheur, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoppe, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenders, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijer, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lepperdinger, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, AnkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-173236
DOI: 10.1002/adfm.201802873
Journal or Publication Title: Adv. Funct. Mater.
Volume: 28
Number: 36
Date: 2018
Publisher: WILEY-V C H VERLAG GMBH
Place of Publication: WEINHEIM
ISSN: 1616-3028
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FLUORESCENT NANODIAMONDS; RENAL CLEARANCE; QUANTUM DOTS; DETONATION; PARTICLES; ELECTRON; BRACHYTHERAPY; IMPLANTATION; MICROSCOPY; PHOSPHATEMultiple languages
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed MatterMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17323

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